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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 276 - 286 (11page)
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초록· 키워드
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CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> regulatory T (Treg) cells play major roles in immune homeostasis. While
CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells. In particular, IL- 17A-producing CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells express RORγt, the T helper (Th) 17-specific transcription factor, in addition to Foxp3. IL-17A-producing CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells are also involved in the pathogenesis of various diseases. Here we review the mechanisms underlying the induction of IL-17A-producing CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells and the roles of these cells in human disease.
CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells. In particular, IL- 17A-producing CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells express RORγt, the T helper (Th) 17-specific transcription factor, in addition to Foxp3. IL-17A-producing CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells are also involved in the pathogenesis of various diseases. Here we review the mechanisms underlying the induction of IL-17A-producing CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells and the roles of these cells in human disease.
목차
ABSTRACT
INTRODUCTION
CD4+FOXP3+ Treg CELLS
THE BIOLOGY OF IL-17A-PRODUCING CD4+FOXP3+ TregCELLS
IL-17A-PRODUCING FOXP3+ Treg CELLS AND HUMANDISEASES
CONCLUSION AND PERSPECTIVE
REFERENCES
참고문헌 (82)
참고문헌 신청
Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-949.
Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 2004;200:277-285.
Kriegel MA, Lohmann T, Gabler C, Blank N, Kalden JR, Lorenz HM. Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J Exp Med 2004;199:1285-1291.
Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, Nochy D, Debre P, Piette JC, Gorochov G. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005;175:8392-8400.
Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004;199:971-979.
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UCI(KEPA) : I410-ECN-0101-2018-517-001400647