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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.2
- 수록면
- 28 - 43 (16page)
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초록· 키워드
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Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) has been spreading worldwide since its outbreak in December 2019, and World Health Organization declared it as a pandemic on March 11, 2020. SARS-CoV-2 is highly contagious and is transmitted through airway epithelial cells as the first gateway. SARS-CoV-2 is detected by nasopharyngeal or oropharyngeal swab samples, and the viral load is significantly high in the upper respiratory tract. The host cellular receptors in airway epithelial cells, including angiotensin-converting enzyme 2 and transmembrane serine protease 2, have been identified by single-cell RNA sequencing or immunostaining. The expression levels of these molecules vary by type, function, and location of airway epithelial cells, such as ciliated cells, secretory cells, olfactory epithelial cells, and alveolar epithelial cells, as well as differ from host to host depending on age, sex, or comorbid diseases. Infected airway epithelial cells by SARSCoV-2 in ex vivo experiments produce chemokines and cytokines to recruit inflammatory cells to target organs. Same as other viral infections, IFN signaling is a critical pathway for host defense. Various studies are underway to confirm the pathophysiological mechanisms of SARS-CoV-2 infection. Herein, we review cellular entry, host-viral interactions, immune responses to SARS-CoV-2 in airway epithelial cells. We also discuss therapeutic options related to epithelial immune reactions to SARS-CoV-2.
목차
ABSTRACT
CELLULAR ENTRY OF SARS-COV-2 VIA AIRWAY EPITHELIAL CELLS
INTERACTION OF EPITHELIAL CELLS AND IMMUNECELLS IN SARS-COV-2 INFECTION
EPITHELIAL CELL-RELATED THERAPEUTIC OPTIONS
CONCLUSION
REFERENCES
참고문헌 (112)
참고문헌 신청
Wang D / 2020 / Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China / JAMA 323:1061~1069
Zhu N / 2020 / A novel coronavirus from patients with pneumonia in China, 2019 / N Engl J Med 382:727~733
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Zhou P / 2020 / A pneumonia outbreak associated with a new coronavirus of probable bat origin / Nature 579:270~273
Larsen JR / 2020 / Modeling the onset of symptoms of COVID-19 / Front Public Health 8:473
Zhu N / 2020 / A novel coronavirus from patients with pneumonia in China, 2019 / N Engl J Med 382:727~733
Wu F / 2020 / A new coronavirus associated with human respiratory disease in China / Nature 579:265~269
Zhou P / 2020 / A pneumonia outbreak associated with a new coronavirus of probable bat origin / Nature 579:270~273
Larsen JR / 2020 / Modeling the onset of symptoms of COVID-19 / Front Public Health 8:473
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UCI(KEPA) : I410-ECN-0101-2021-517-001563462