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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.2
- 수록면
- 144 - 156 (13page)
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초록· 키워드
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The coronavirus disease 2019 (COVID-19) pandemic (severe acute respiratory syndrome coronavirus 2) is a global infectious disease with rapid spread. Some patients have severe symptoms and clinical signs caused by an excessive inflammatory response, which increases the risk of mortality. In this study, we reanalyzed scRNA-seq data of cells from bronchoalveolar lavage fluids of patients with COVID-19 with mild and severe symptoms, focusing on Ab-producing cells. In patients with severe disease, B cells seemed to be more activated and expressed more immunoglobulin genes compared with cells from patients with mild disease, and macrophages expressed higher levels of the TNF superfamily member B-cell activating factor but not of APRIL (a proliferation-inducing ligand). In addition, macrophages from patients with severe disease had increased pro-inflammatory features and pathways associated with Fc receptor-mediated signaling, compared with patients with mild disease. CCR2-positive plasma cells accumulated in patients with severe disease, probably because of increased CCL2 expression on macrophages from patients with severe disease. Together, these results support the hypothesis that different characteristics of B cells might be associated with the severity of COVID-19 infection.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
Zhao J / 2020 / Antibody responses to SARSCoV-2 in patients of novel coronavirus disease 2019 / Clin Infect Dis 71:2027~2034
World Health Organization / 2020 / Coronavirus disease (COVID-19) situation
Mehta P / 2020 / COVID-19: consider cytokine storm syndromes and immunosuppression / Lancet 395:1033~1034
Lee JS / 2020 / Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 / Sci Immunol 5:eabd1554
Liao M / 2020 / Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 / Nat Med 26:842~844
World Health Organization / 2020 / Coronavirus disease (COVID-19) situation
Mehta P / 2020 / COVID-19: consider cytokine storm syndromes and immunosuppression / Lancet 395:1033~1034
Lee JS / 2020 / Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 / Sci Immunol 5:eabd1554
Liao M / 2020 / Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 / Nat Med 26:842~844
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UCI(KEPA) : I410-ECN-0101-2021-517-001563533