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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 232 - 235 (4page)
- DOI
- https://doi.org/10.3904/kjm.2020.95.4.232
이용수
초록· 키워드
오류제보하기
A role of angiotensin-converting enzyme 2 (ACE2) in the coronavirus disease 2019 pandemic has been suggested, because it is the molecular receptor for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2). ACE2 is known to provide a protective effect for cardiac and vascular tissues, because it generally counteracts angiotensin II (Ang II) activity. ACE2 downregulation has been implicated in the pathogenesis of cardiovascular disease. ACE inhibitors and angiotensin receptor blockers may enhance ACE2 mRNA expression and enzyme activity. However, this has not been demonstrated in lung tissue. In the lungs, Ang II induces vasoconstriction to prevent ventilation perfusion mismatch, while also increasing vascular permeability (which can precipitate pulmonary edema). ACE2 is expressed in 0.67% of human lung cells, 80% of which are type 2 alveolar cells. Men (of all ethnicities) and Asian individuals have been shown to express higher levels of ACE2 than women and non-Asian individuals, respectively.
However, there are no data from human studies indicating that high ACE2 expression increases the likelihood of SARS-CoV2 infection. In animal studies, an increase in Ang II caused by SARS-CoV2 or spike protein interactions, in turn due to ACE2 downregulation, has been identified as the key mechanism underlying lung injury. In human studies of SARS-CoV2 infection, ACE2 overexpression was shown to cause inflammatory apoptosis and a cytokine storm. The actions of ACE2 and Ang II in SARS-CoV2-infected vascular and lung tissues differ between animals and humans. ACE2 expression levels pre- and post-SARS-CoV2 infection should be differentiated.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Wan Y / 2020 / Receptor recognition by the novel coronavirus from Wuhan : an analysis based on decade-long structural studies of SARS coronavirus / J Virol 94:e00127~20
Fang L / 2020 / Are patients with hypertension and diabetes mellitus at increased risk for COVID-19infection / Lancet Respir Med 8:e21
Donoghue M / 2000 / A novel angiotensin-converting enzyme-related carboxypeptidase(ACE2)converts angiotensin I to angiotensin 1-9 / Circ Res 87:E1
Hamming I / 2004 / Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis / J Pathol 203:631~637
Marian AJ / 2013 / The discovery of the ACE2 gene / Circ Res 112:1307~1309
Fang L / 2020 / Are patients with hypertension and diabetes mellitus at increased risk for COVID-19infection / Lancet Respir Med 8:e21
Donoghue M / 2000 / A novel angiotensin-converting enzyme-related carboxypeptidase(ACE2)converts angiotensin I to angiotensin 1-9 / Circ Res 87:E1
Hamming I / 2004 / Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis / J Pathol 203:631~637
Marian AJ / 2013 / The discovery of the ACE2 gene / Circ Res 112:1307~1309
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