지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience Vol.22 No.3
- 발행연도
- 2024.8
- 수록면
- 473 - 483 (11page)
- DOI
- 10.9758/cpn.23.1149
이용수
초록· 키워드
오류제보하기
Objective: This study aimed to compare serum levels of CD163, YKL-40, and VILIP-1 between children with autism spectrum disorder (ASD) and healthy controls, while also investigating their association with the severity of ASD and language development.
Methods: The study included 40 ASD-diagnosed patients (aged 18−72 months) and 40 age-matched healthy controls.
Childhood Autism Rating Scale, Preschool Language Scale-4, and Ankara Development Screening Inventory were ad ministered to children in the ASD group. Serum CD163, YKL-40 and VILIP-1 levels were measured with an en zyme-linked immunosorbent assay kit.
Results: In the ASD group compared to the control group, serum VILIP-1 levels were significantly higher (p = 0.046).
No significant differences were observed in mean serum CD163 and YKL-40 levels between patients and controls (p = 0.613, p = 0.769). Interestingly, a positive correlation was observed between CD163 and YKL-40 levels and ASD se verity (p ＜ 0.001 for both). Additionally, CD163 and YKL-40 levels showed significant predictive value for ASD severity.
While no significant associations were found between CD163 and YKL-40 levels and language development, a negative correlation was observed between VILIP-1 levels and language development (p ＜ 0.001).
Conclusion: Our findings highlight that the levels of CD163 and YKL-40 significantly predicted ASD severity, indicating a potential role of neuroinflammation in the development of ASD.
목차
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