지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 257 - 263 (7page)
이용수
초록· 키워드
오류제보하기
Objective. To examine the relationship of serum/plasma YKL-40 levels with rheumatoid arthritis (RA) and their correlation with RA activity and rheumatoid factor (RF) level. Methods. We performed a meta-analysis comparing the serum/plasma YKL-40 levels between patients with RA and controls and examined the correlation coefficients of the circulating YKL-40 level with the RF level and RA activity based on the 28-joint disease activity score (DAS28), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) level. Results. Nine studies (707 patients with RA and 1,041 controls) were included in the meta-analysis. The YKL-40 levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD]=1.071, 95% confidence interval [CI]=0.726∼1.417, p＜0.001). Stratification by ethnicity showed significantly elevated YKL-40 levels in the RA groups from European, Asian, North American, and Arab populations. The YKL-40 level was significantly higher in the RA group than in the control group in both age- and sex-matched and only age-matched populations (SMD=0.937, 95% CI=0.554∼1.320, p＜0.001; SMD=2.951, 95% CI=1.389∼4.512, p＜0.001, respectively). Subgroup analysis by sample size showed significantly increased YKL-40 levels in the RA group in both small (n＜100) and large (n＞100) populations. Meta-analysis of correlation coefficients showed a significant positive correlation between the YKL-40 levels and DAS28, ESR, CRP level, and RF level (DAS28: correlation coefficient=0.381, 95% CI=0.044∼0.640, p=0.028; RF level: correlation coefficient=0.341, 95% CI=0.176∼0.487, p＜0.001). Conclusion. The circulating YKL-40 levels are high in patients with RA and positively correlate with RA activity and RF level.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Lee YH / 2012 / Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis / Mol Biol Rep 39:10627~10635
Hakala BE / 1993 / Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family / J Biol Chem 268:25803~25810
Johansen JS / 2006 / Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer / Dan Med Bull 53:172~209
Zivanović S / 2009 / Human cartilage glycoprotein 39--biomarker of joint damage in knee osteoarthritis / Int Orthop 33:1165~1170
Furuhashi K / 2010 / Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis / Respir Med 104:1204~1210
Hakala BE / 1993 / Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family / J Biol Chem 268:25803~25810
Johansen JS / 2006 / Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer / Dan Med Bull 53:172~209
Zivanović S / 2009 / Human cartilage glycoprotein 39--biomarker of joint damage in knee osteoarthritis / Int Orthop 33:1165~1170
Furuhashi K / 2010 / Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis / Respir Med 104:1204~1210
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis
Journal of Veterinary Science
2019 .09
-
Investigating the Relationship of Serum CD163, YKL40 and VILIP-1 Levels with Autism Severity and Language-cognitive Development in Preschool Children with Autism
Clinical Psychopharmacology and Neuroscience
2024 .08
-
Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children
Annals of Laboratory Medicine
2018 .01
-
Anti-Inflammatory Effect of Vitamin D via Suppression of YKL-40 Production: One of the Possible Mechanisms for Cardiovascular Protection
Korean Circulation Journal
2023 .02
-
천식 소아에서 혈청 vascular endothelial growth factor, transforming growth factor-beta1과 YKL-40 증가의임상적 의의
Allergy Asthma & Respiratory Diseases
2015 .01
-
Circulating leptin and its correlation with rheumatoid arthritis activity: a meta-analysis
대한류마티스학회지
2023 .04
-
Circulating Interleukin-37 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Correlations With Disease Activity: A Meta-analysis
대한류마티스학회지
2020 .01
-
Association between the Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio and Rheumatoid Arthritis and their Correlations with the Disease Activity: A Meta-analysis
대한류마티스학회지
2018 .01
-
Clinical Significance of Elevated Serum Immunoglobulin G4 Levels in Patients With Rheumatoid Arthritis
대한류마티스학회지
2020 .01
-
Rheumatoid arthritis in tight disease control is no longer risk of bone mineral density loss
Osteoporosis and Sarcopenia
2020 .01
-
Characteristics of Appendicular Tissue Components in Patients with Rheumatoid Arthritis
대한골대사학회지
2020 .01
-
Mortality in Korean Patients With Rheumatoid Arthritis
대한류마티스학회지
2021 .01
-
Clinical and immunological responses to COVID-19 vaccination in rheumatoid arthritis patients on disease modifying antirheumatic drugs: a cross-sectional study
대한류마티스학회지
2024 .01
-
Relationship between Metabolic Syndrome and Rheumatoid Arthritis
Korean Journal of Family Medicine
2016 .01
-
Effect of Vitamin D on YKL-40: Rat Hypercholesterolemia Model
Korean Circulation Journal
2023 .02
-
Comparison of Disease Activity Score 28 Using C-reactive Protein and Disease Activity Score 28 Using Erythrocyte Sedimentation Rate in Assessing Activity and Treatment Response in Rheumatoid Arthritis: A Meta-analysis
대한류마티스학회지
2016 .01
-
Disease Characteristics and Change in Arthritis Activity according to Treatment in Hepatitis B Surface Antigen-positive Rheumatoid Arthritis Patients: a Retrospective Chart Review Study
Journal of Korean Medical Science
2018 .01
-
Associations of periodontal status in periodontitis and rheumatoid arthritis patients
Journal of Periodontal & Implant Science
2021 .01
-
Hypereosinophilic Syndrome Associated with the Onset of Rheumatoid Arthritis: A Case Report
대한류마티스학회지
2017 .01
-
Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery
대한신경외과학회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0