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학술저널
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대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제6호
발행연도
2015.1
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417 - 424 (8page)

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Purpose: Vascular endothelial growth factor (VEGF), transforming growth factor beta1 (TGF-β1), and platelet derived growth factor (PDGF) are known to be involved in the pathogenesis of inflammation and remodeling in asthmatic airways. YKL-40, a chitinase-like protein, and clusterin have been reported to be biomarkers for severe asthma. We examined the serum levels of growth factors, YKL-40, and clusterin in children with acute asthma or stable asthma, and investigated their correlation with clinical findings and lung function parameters. Methods: Forty-one children (≥6 years of age) with asthma were enrolled, and 2 groups were defined: 23 patients admitted with acute asthma (acute asthma group) and 18 patients with stable asthma (stable asthma group). The serum levels of VEGF, TGF-β1, PDGF-BB, YKL-40, and clusterin were measured using enzyme-linked immunosorbent assay and assessed in relation to clinical manifestations and spirometric parameters. Fifteen age-matched controls were also studied. Results: The serum levels of VEGF, TGF-β1, and YKL-40 were significantly elevated in children with acute asthma compared to controls. The serum levels of VEGF and YKL-40 were higher in the stable asthma group than in controls. The serum levels of VEGF, TGF-β1, and YKL-40 were not different between the acute asthma and stable asthma groups. The serum VEGF levels in the acute asthma group correlated significantly with asthma severity. The serum TGF-β1 levels in stable asthma group showed a significant inverse correlation with (FEV1) forced expiratory volume in one second and FEF25%–75% (forced expiratory flow between 25 and 75 percent of expired vital capacity). Serum YKL-40 had no significant relationship with clinical manifestations and spirometric parameters. Conclusion: Our study suggests that increased serum levels of VEGF and YKL-40 might affect asthmatic airways not only during acute exacerbation but also in stable state and that serum TGF-β1 might be a biomarker for airway obstruction in children with asthma.
#Asthma #Vascular endothelial growth factor #Transforming growth factor beta1 #YKL-40

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참고문헌 (23)

참고문헌 신청
Abdel-Rahman AM / 2006 / A comparative study of two angiogenic factors : vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute google schola Asai K / 2003 / Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients / Clin Exp Allergy 33 : 595 ~ 599 google schola Barbato A / 2006 / Epithelial damage and angiogenesis in the airways of children with asthma / Am J Respir Crit Care Med 174 : 975 ~ 981 google schola Burgess JK / 2009 / The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma / Pharmacol Ther 122 : 19 ~ 2 google schola Chung HL / 2015 / Increased epidermal growth factor in nasopharyngeal aspirates from infants with recurrent wheeze / Pediatr Pulmonol 50 : 841 ~ 847 google schola

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