Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis

Kai-Chung Cheng; Jih-Jong Lee; Shang-Lin Wang; Chun-Yu Lin; Ching-Tien Tseng; Chen-Si Lin; Albert Taiching Liao

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자료유형: 학술저널

저자정보: Kai-Chung Cheng (National Taiwan University) Jih-Jong Lee (National Taiwan University) Shang-Lin Wang (National Taiwan University) Chun-Yu Lin (National Taiwan University) Ching-Tien Tseng (National Taiwan University) Chen-Si Lin (National Taiwan University) Albert Taiching Liao (National Taiwan University)

저널정보: 대한수의학회 Journal of Veterinary Science Journal of Veterinary Science 제20권 제5호

발행연도: 2019.9

수록면: 86 - 95 (10page)

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YKL-40, a secreted glycoprotein, may serve as an autoantigen, which mediates multiple inflammatory diseases and cancers. A high YKL-40 serum level is correlated with metastasis and poor survival in a variety of human cancers. However, the role of YKL-40 in dogs is still under evaluation. Herein, we examined the associations between plasma YKL-40 level and YKL-40 autoantibody (YAA) titers with malignancy and prognosis in canine cancer. Plasma levels of YKL-40 in healthy dogs (n = 20) and in dogs (n = 82) with cancer were evaluated using enzyme-linked immunosorbent assay. Our results indicated that plasma YKL-40 levels were significantly higher (p < 0.01) in dogs with cancer than in healthy dogs. A significant decrease in the YAA titers was detected in the dogs with cancer when compared with those of the healthy dogs (p < 0.05), although the change was not correlated with the YKL-40 levels. Among the dogs with cancer, plasma YKL-40 levels in the dogs that later relapsed or had metastasis were significantly higher than in the dogs with no signs of relapse (p < 0.01) or metastasis (p <0.05). The relapse and metastasis rates were significantly higher in the high YKL-40 group (> 180 pg/mL) than in the low YKL-40 group (< 180 pg/mL). The results imply that plasma YKL-40 levels might have the potential to be developed as a marker of malignancy progression and prognosis in canine cancers.

#YKL-40 #autoantibodies #autoantigens #canine cancer #prognosis

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