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논문 기본 정보

자료유형
학술저널
저자정보
Li Lei (School of Pharmacy, Jiangxi Science and Technology Normal University Nanchang, Jiangxi, China) Ji Xiaofan (School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China) Rao Xiaoyong (School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China) Luo Dewei (School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China) Mao Qiping (School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China) Du Hui (School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China) Fang Haihong (School of Pharmacy, Jiangxi Science and Technology Normal University Nanchang, Jiangxi, China) Ouyang Hui (School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China) Zhang Yuan (The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China)
저널정보
대한약침학회 Journal of Acupuncture & Meridian Studies Innovations in Acupuncture and Medicine Vol.17 No.4
발행연도
2024.8
수록면
133 - 140 (8page)
DOI
10.51507/j.jams.2024.17.4.133

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Importance: Choledocholithiasis, or bile duct gallstones, is effectively treated with surgery, which does not prevent relapse. A common adjuvant therapy is the stimulation of the Yanglingquan point (GB34). Acupoint catgut embedding (ACE), an acupoint stimulation therapy, may be a better treatment for choledocholithiasis. Objectives: To investigate the effect of ACE in stimulating GB34 on bile metabolism and its possible mechanism via metabonomics. Methods: In this study, we used ultrahigh performance liquid chromatographyquadrupole time-of-flight mass spectrometry (UHPLC-MS/MS) to analyze the changes in bile metabolites, metabolic pathways, and liver function indicators in 16 patients with choledocholithiasis before and after ACE stimulation. Results: We identified 10 metabolites that exhibited significant differences in the bile before and after ACE, six of which significantly increased and four that significantly decreased. Moreover, six liver function indicators showed a downward trend. We identified related metabolic pathways as glycerophospholipid metabolism, steroid biosynthesis, and the citrate cycle (TCA cycle). Conclusions and Relevance: This study shows that ACE stimulation of GB34 can effectively help treat choledocholithiasis, which may be clinically applicable to ACE.

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