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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 569 - 575 (7page)
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Background/Aims: Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile acid transport proteins in cholangiocytes from normal rat liver and analyzed the possible pathophysiological significance. Methods: Bile duct tissues of Sprague-Dawley rats were isolated by enzymatic digestion and mechanical isolation, and then divided into large and small bile duct tissues. Immunohistochemistry, real-time polymerase chain reaction and Western blotting were used to determine the expression of the apical sodium-dependent bile acid transporter (ASBT), ileal bile acid binding protein (IBABP), and basolateral organic solute transporter α (Ostα) in the biliary tract system of rats. Differences in the expression and distribution of these proteins were analyzed. Results: In cholangiocytes, ASBT and IBABP were mainly expressed in cholangiocytes of the large bile ducts, in which the expression of both was significantly higher than that in the small ducts (p<0.05). Ostα was simultaneously expressed in cholangiocytes of both the large and small bile ducts, showing no significant difference in expression between the two groups of bile ducts (p>0.05). Conclusions: Bile acid transporters are expressed and heterogeneously distributed in rat bile ducts, indicating that bile acid reabsorption by cholangiocytes might mainly occur in the large bile ducts. These findings may help explore the physiology of bile ducts and the pathogenesis of various cholangiopathies.
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참고문헌 (24)
참고문헌 신청
Alvaro D / 2000 / Regulation and deregulation of cholangiocyte proliferation / J Hepatol 33:333~340
Maroni L / 2015 / Functional and structural features of cholangiocytes in health and disease / Cell Mol Gastroenterol Hepatol 1:368~380
Han Y / 2013 / Recent advances in the morphological and functional heterogeneity of the biliary epithelium / Exp Biol Med 238:549~565
Priester S / 2010 / Involvement of cholangiocyte proliferation in biliary fibrosis / World J Gastrointest Pathophysiol 1:30~37
Benedetti A / 1996 / A morphometric study of the epithelium lining the rat intrahepatic biliary tree / J Hepatol 24:335~342
Maroni L / 2015 / Functional and structural features of cholangiocytes in health and disease / Cell Mol Gastroenterol Hepatol 1:368~380
Han Y / 2013 / Recent advances in the morphological and functional heterogeneity of the biliary epithelium / Exp Biol Med 238:549~565
Priester S / 2010 / Involvement of cholangiocyte proliferation in biliary fibrosis / World J Gastrointest Pathophysiol 1:30~37
Benedetti A / 1996 / A morphometric study of the epithelium lining the rat intrahepatic biliary tree / J Hepatol 24:335~342
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