Lack of Influence of the ACE1 Gene I/D Polymorphism on the Formation and Growth of Benign Uterine Leiomyoma in Turkish Patients

Gultekin, Guldal Inal; Yilmaz, Seda Gulec; Kahraman, Ozlem Timirci; Atasoy, Hande; Dalan, A. Burak; Attar, Rukset; Buyukoren, Ahmet; Ucunoglu, Nazli; Isbir, Turgay

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자료유형: 학술저널

저자정보: Gultekin, Guldal Inal (Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University) Yilmaz, Seda Gulec (Department of Molecular Medicine, Institute of Health Sciences, Faculty of Medicine, Yeditepe University) Kahraman, Ozlem Timirci (Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University) Atasoy, Hande (Department of Molecular Medicine, Institute of Health Sciences, Faculty of Medicine, Yeditepe University) Dalan, A. Burak (Yeditepe University Hospital, Faculty of Medicine, Yeditepe University) Attar, Rukset (Department of Gynecology, Faculty of Medicine, Yeditepe University) Buyukoren, Ahmet (Department of Gynecology, Faculty of Medicine, Istanbul University) Ucunoglu, Nazli (Department of Molecular Medicine, Institute of Health Sciences, Faculty of Medicine, Yeditepe University) Isbir, Turgay (Department of Medical Biology, Faculty of Medicine, Yeditepe University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 1,123 - 1,127 (5page)

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Uterine leiomyomas (ULM), are benign tumors of the smooth muscle cells of the myometrium. They represent a common health problem and are estimated to be present in 30-70% of clinically reproductive women. Abnormal angiogenesis and vascular-related growth factors have been suggested to be associated with ULM growth. The angiotensin-I converting enzyme (ACE) is related with several tumors. The aim of this study was to identify possible correlation between ULM and the ACE I/D polymorphism, to evaluate whether the ACE I/D polymorphism could be a marker for early diagnosis and prognosis. ACE I/D was amplified with specific primer sets recognizing genomic DNA from ULM (n=72) and control (n=83) volunteers and amplicons were separated on agarose gels. The observed genotype frequencies were in agreement with Hardy-Weinberg equilibrium ($x^2=2.162$, p=0.339). There was no association between allele frequencies and study groups ($x^2=0.623$; p=0.430 for ACE I allele, $x^2=0.995$; p=0.339 for ACE D allele). In addition, there were no significant differences between ACE I/D polymorphism genotype frequencies and ULM range in size and number ($X^2=1.760;$ p=0.415 for fibroid size, $X^2=0.342;$ p=0.843 for fibroid number). We conclude that the ACE gene I/D polymorphism is not related with the size or number of ULM fibroids in Turkish women. Thus it cannot be regarded as an early diagnostic parameter nor as a risk estimate for ULM predisposition.

#Angiogenesis #benign cancer #uterine fibroid #uterine myoma #ACE insertion/deletion

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