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논문 기본 정보

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학술저널
저자정보
Seok Jin Myoung (Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, Cheonan, Korea) Waters Patrick (Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom) Jeon Mi Young (Department of Neurology, Neuroscience Center, Samsung Medical Center, Seoul, Korea) Lee Hye Lim (Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.) Baek Seol-Hee (Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea) Park Jin-Sung (Department of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea) Kang Sa-Yoon (Department of Neurology, Jeju National University School of Medicine, Jeju, Korea) Kwon Ohyun (Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea.) Oh Jeeyoung (Department of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.) Park Kyung-Ah (Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Oh Sei Yeul (Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Kim Byoung Joon (Department of Neurology, Neuroscience Center, Samsung Medical Center, Seoul, KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) Min Ju-Hong (Department of Neurology, Neuroscience Center, Samsung Medical Center, Seoul, KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDep)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제44권 제1호
발행연도
2024.1
수록면
56 - 63 (8page)
DOI
10.3343/alm.2024.44.1.56

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Background: The clinical implications of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Abs) are increasing. Establishing MOG-Ab assays is essential for effectively treating patients with MOG-Abs. We established an in-house cell-based assay (CBA) to detect MOG-Abs to identify correlations with patients’ clinical characteristics. Methods: We established the CBA using HEK 293 cells transiently overexpressing full-length human MOG, tested it against 166 samples from a multicenter registry of central nervous system (CNS) inflammatory disorders, and compared the results with those of the Oxford MOG-Ab-based CBA and a commercial MOG-Ab CBA kit. We recruited additional patients with MOG-Abs and compared the clinical characteristics of MOG-Ab-associated disease (MOGAD) with those of neuromyelitis optica spectrum disorder (NMOSD). Results: Of 166 samples tested, 10 tested positive for MOG-Abs, with optic neuritis (ON) being the most common manifestation (4/15, 26.7%). The in-house and Oxford MOG-Ab CBAs agreed for 164/166 (98.8%) samples (κ=0.883, P<0.001); two patients (2/166, 1.2%) were only positive in our in-house CBA, and the CBA scores of the two laboratories correlated well (r=0.663, P<0.001). The commercial MOG-Ab CBA kit showed one false-negative and three false-positive results. The clinical presentation at disease onset differed between MOGAD and NMOSD; ON was the most frequent manifestation in MOGAD, and transverse myelitis was most frequent in NMOSD. Conclusions: The in-house CBA for MOG-Abs demonstrated reliable results and can potentially be used to evaluate CNS inflammatory disorders. A comprehensive, long-term study with a large patient population would clarify the clinical significance of MOG-Abs.
#Autoantibody #Central nervous system disease #Immunoassay #Myelin oligodendrocyte glycoprotein

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