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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 231 - 238 (8page)
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초록· 키워드
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Myelin is a specialized structure of the nervous system that both enhances electrical conductance and insulates neurons from external risk factors. In the central nervous system, polarized oligodendrocytes form myelin by wrapping processes in a spiral pattern around neuronal axons through myelin-related gene regulation. Since these events occur at a distance from the cell body, post-transcriptional control of gene expression has strategic advantage to fine-tune the overall regulation of protein contents in situ. Therefore, many research interests have been focused to identify RNA binding proteins and their regulatory mechanism in myelinating compartments. Fragile X mental retardation protein (FMRP) is one such RNA binding protein, regulating its target expression by translational control. Although the majority of works on FMRP have been performed in neurons, it is also found in the developing or mature glial cells including oligodendrocytes, where its function is not well understood. Here, we will review evidences suggesting abnormal translational regulation of myelin proteins with accompanying white matter problem and neurological deficits in fragile X syndrome, which can have wider mechanistic and pathological implication in many other neurological and psychiatric disorders.
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참고문헌 (73)
참고문헌 신청
Barateiro, A. / 2016 / Oligodendrocyte development and myelination in neurodevelopment: molecular mechanisms in health and disease / Curr. Pharm. Des 22:656~679
Barbarese, E. / 1995 / Protein translation components are colocalized in granules in oligodendrocytes / J. Cell Sci 108:2781~2790
Barrette, B. / 2013 / Molecular triggers of neuroinflammation in mouse models of demyelinating diseases / Biol. Chem 394:1571~1581
Bicker, S. / 2014 / MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendrites / Cell. Mol. Life Sci 71:3987~4005
Brown, S. S. / 2015 / Fragile X premutation carriers:A systematic review of neuroimaging findings / J. Neurol. Sci 352:19~28
Barbarese, E. / 1995 / Protein translation components are colocalized in granules in oligodendrocytes / J. Cell Sci 108:2781~2790
Barrette, B. / 2013 / Molecular triggers of neuroinflammation in mouse models of demyelinating diseases / Biol. Chem 394:1571~1581
Bicker, S. / 2014 / MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendrites / Cell. Mol. Life Sci 71:3987~4005
Brown, S. S. / 2015 / Fragile X premutation carriers:A systematic review of neuroimaging findings / J. Neurol. Sci 352:19~28
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