지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한구강생물학회 International Journal of Oral Biology International Journal of Oral Biology Vol.49 No.1
- 발행연도
- 2024.3
- 수록면
- 18 - 25 (8page)
이용수
초록· 키워드
오류제보하기
Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC has remained almost unchanged for several decades, and many side effects of chemotherapy still exist. In this study, three-dimensional (3D) models of OSCC were established using fibroblasts, and the efficacy of various biological inhibitors was evaluated. A culture of epithelial cells with two types of fibroblasts (hTERT-hNOFs and cancer-associated fibroblasts) within a type I collagen matrix resulted in the formation of a continuous layer of tightly packed cells compared to models without fibroblasts. Furthermore, the effects of biological chemicals, including Y27632, latrunculin A, and verteporfin, on these models were investigated. The stratified formation of the epithelial layer and invasion in OSCC 3D-culture models were effectively inhibited by verteporfin, whereas invasion was weakly inhibited by Y27632 and latrunculin. Collectively, the developed OSCC 3D-culture models established with fibroblasts demonstrated the potential for drug screening, with verteporfin showing promising efficacy.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Role of proteases, cytokines, and growth factors in bone invasion by oral squamous cell carcinoma
International Journal of Oral Biology
2019 .01
-
Salivary biomarkers in oral squamous cell carcinoma
대한구강악안면외과학회지
2020 .10
-
Tivozanib-induced activation of the mitochondrial apoptotic pathway and suppression of epithelial-to-mesenchymal transition in oral squamous cell carcinoma
The Korean Journal of Physiology & Pharmacology
2024 .05
-
Cathepsin D Expression in Oral Squamous Cell Carcinoma and Cancer-Associated Fibroblasts: A Preliminary Study
치위생과학회지
2021 .12
-
Oral squamous carcinoma cells stimulated by Porphyromonas gingivalis-derived lipopolysaccharide induce osteoclastogenesis through a paracrine mechanism
International Journal of Oral Biology
2024 .09
-
Methanol extracts of Sedum oryzifolium and its constituents, quercetin, attenuates the invasion of oral cancer cells through blocking Slug expression
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
대한구강악안면외과학회지
2022 .02
-
Genetic Variation in MicroRNAs and Risk of Oral Squamous Cell Carcinoma in South Indian Population
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Are p53 Antibodies a Diagnostic Indicator for Patients with Oral Squamous Cell Carcinoma? Systematic Review and Meta-Analysis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Antitumor effect of E7080 in oral carcinoma xenograft model
Oral Biology Research
2016 .01
-
Overall and disease-specific survival outcomes following primary surgery for oral squamous cell carcinoma: analysis of consecutive 67 patients
대한구강악안면외과학회지
2019 .01
-
Roles of Human Papillomaviruses and p16 in Oral Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Expression of Matrix Metalloproteinase-10 at Invasive Front of Squamous Cell Carcinoma and Verrucous Carcinoma in the Oral Cavity
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Immunohistochemical Evaluation of Glucose Transporter Type 1 in Epithelial Dysplasia and Oral Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Cancerous Inhibitor of Protein Phosphatase 2A as a Molecular Marker for Aggressiveness and Survival in Oral Squamous Cell Carcinoma
대한암예방학회지
2020 .01
-
A Case of Oculomotor Nerve Paralysis Caused by Cavernous Sinus Metastasis of Tonsil Cancer
Journal of Rhinology
2022 .03
-
Adenosine Deaminase - a Novel Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Decreased expression of SOX7 correlates with vasculogenic mimicry and poor prognosis in oral squamous cell carcinoma
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Autophagy Inhibition by Cudraxanthone D Regulates Epithelial Mesenchymal Transition in SCC25 Cell
International Journal of Oral Biology
2021 .01
-
Lipopeptides Extract from Bacillus Amyloliquefaciens Induce Human Oral Squamous Cancer Cell Death
Asian Pacific journal of cancer prevention : APJCP
2015 .01
최근 본 자료
댓글(0)
0