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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 37 - 42 (6page)
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Oral squamous cell carcinoma (OSCC) is the most common oral malignancy and an increasing global public health problem. OSCC frequently invades the jaw bone. OSCC-induced bone invasion has a significant impact on tumor stage, treatment selection, patient outcome, and quality of life. A number of studies have shown that osteoclast-mediated bone resorption is a major step in the progression of bone invasion by OSCC; however, the molecular mechanisms involved in OSCC bone invasion are not yet clear. In this review, we present the clinical types of OSCC bone invasion and summarize the role of key molecules, including proteases, cytokines, and growth factors, in the sequential process of bone invasion. A better understanding of bone invasion will facilitate the discovery of molecular targets for early detection and treatment of OSCC bone invasion.
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참고문헌 (50)
참고문헌 신청
Jacques Ferlay / 2015 / Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 / International Journal of Cancer 136(5):E359~E386
Saman Warnakulasuriya / 2009 / Global epidemiology of oral and oropharyngeal cancer / Oral Oncology 45(4-5):309~316
EIJIRO JIMI / 2013 / The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma / International Journal of Oncology 42(3):803~809
Esra Attar / 2010 / Head and neck cancer in a developing country: A population-based perspective across 8years / Oral Oncology 46(8):591~596
S. Choi / 2008 / Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy / Journal of Dental Research 87(1):14~32
Saman Warnakulasuriya / 2009 / Global epidemiology of oral and oropharyngeal cancer / Oral Oncology 45(4-5):309~316
EIJIRO JIMI / 2013 / The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma / International Journal of Oncology 42(3):803~809
Esra Attar / 2010 / Head and neck cancer in a developing country: A population-based perspective across 8years / Oral Oncology 46(8):591~596
S. Choi / 2008 / Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy / Journal of Dental Research 87(1):14~32
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