Cancerous Inhibitor of Protein Phosphatase 2A as a Molecular Marker for Aggressiveness and Survival in Oral Squamous Cell Carcinoma

Rajab Alzahrani; Amani A. Alrehaili; Amal F. Gharib; Farah Anjum; Khadiga A. Ismail; Wael H. Elsawy

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자료유형: 학술저널

저자정보: Rajab Alzahrani (Albaha University) Amani A. Alrehaili (Taif University) Amal F. Gharib (Taif University) Farah Anjum (Taif University) Khadiga A. Ismail (Taif University) Wael H. Elsawy (Zagazig University)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제25권 제1호

발행연도: 2020.1

수록면: 21 - 26 (6page)

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Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as one of the most commonly altered proteins in human cancers. It blocks the tumor-suppressive action of protein phosphatase 2A (PP2A) complex and enhances malignancy. Thirty-five patients with squamous cell carcinoma of the oral cavity underwent surgical resection of the tumor. CIP2A was assessed by quantitative real-time PCR in the resected tumor tissues and in their adjacent normal tissues. CIP2A was found to be overexpressed in all oral squamous cell carcinoma (OSCC) specimens in comparison to their surrounding normal tissue. CIP2A overexpression was statistically correlated with poor prognostic feature of the tumor. Thus, a high expression level of CIP2A was associated with shorter survival. In conclusion, CIP2A is upregulated in OSCC, and its overexpression is correlated with aggressiveness of the tumor and poor outcome and survival. It may serve as a prognostic marker of OSCC. Key Words Cancerous inhibitor of protein phosphatase 2A, Oral squamous cell carcinoma

#Cancerous inhibitor of protein phosphatase 2A #Oral squamous cell carcinoma

참고문헌 (39)

참고문헌 신청

Adel M / 2015 / Evaluation of lymphatic and vascular invasion in relation to clinicopathological factors and treatment outcome in oral cavity squamous cell carcinoma / Medicine(Baltimore) 94:e1510

Gharat SA / 2016 / Oral squamous cell carcinoma : current treatment strategies and nanotechnologybased approaches for prevention and therapy / Crit Rev Ther Drug Carrier Syst 33:363~400

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Sontag JM / 2006 / Regulation of cell adhesion by PP2A and SV40 small tumor antigen : an important link to cell transformation / Cell Mol Life Sci 63:2979~2991

Westermarck J / 2008 / Multiple pathways regulated by the tumor suppressor PP2A in transformation / Trends Mol Med 14:152~160

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