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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 95 - 95 (1page)
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Sedum species are reported to possess diverse pharmacological activities in various solid tumors. However, the anti-cancer function of Sedum orizyfolium and its constituents have never been determined in human cancers. The present study focused on addressing the inhibitory effect of the methanol extract of S. orizyfolium (MESO) and its constituent and the underlying molecular mechanism in invasion and epithelial-to-mesenchymal transition (EMT) in oral squamous cell carcinoma (OSCC) cell lines. After MESO treatment, a wound-healing assay, an invasion assay, Western blot, and immunocytochemistry were performed in OSCC cell lines, coupled with in silico analysis and immunohistochemistry in OSCC patient samples, to investigate the role of EMT transcription factor Slug. Quercetin, an active component of MESO, was identified through ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-528-001569832