지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.12
- 수록면
- 160 - 168 (9page)
- DOI
- 10.22889/KJP.2023.54.4.160
이용수
초록· 키워드
오류제보하기
Mast cells plays a key role in the immediate-type hypersensitivity. Fraxin, the active constituent isolated from Cortex Fraxini, has been known to have anti-inflammatory capacity. However, the effects of fraxin in mast cell-mediated anaphylactic reaction have not been fully shown. Therefore, the in vivo anti-anaphylactic activity of fraxin was evaluated using rodent models of anaphylaxis. Additionally, we assessed the mechanism underlying the mast cell stabilizing effect of fraxin, with a specific focus on histamine release from rat peritoneal mast cells (RPMC). Systemic anaphylaxis-like reaction, plasma histamine levels, and ear swelling response were attenuated in mice treated with fraxin. Fraxin also suppressed passive systemic and cutaneous anaphylaxis. Furthermore, fraxin dose-dependently blocked histamine release from RPMC evoked by histamine liberators or the antigen-antibody reaction, which is in agreement with in vivo findings. To elucidate the mechanism of action of fraxin, both calcium influx and intracellular cAMP content in RPMC were assessed. In RPMC stimulated by compound 48/80 or ionophore A23187, fraxin decreased calcium uptake into the cells. Moreover, fraxin increased the intracellular cAMP level and significantly prevented compound 48/80-induced cAMP reduction in RPMC. Taken together, the inhibition of histamine release by fraxin appears to be mediated partly through the suppression of calcium uptake as well as the augmentation of cAMP levels. In conclusions, the clinical application of fraxin in the immediate-type hypersensitivity may be feasible.
목차
Abstract
재료 및 방법
결과
고찰
결론
인용문헌
참고문헌 (25)
참고문헌 신청
Jin, H. J. (2016) Anaphylaxis: diagnosis, management, and current barriers. Allergy Asthma Respir. Dis. 4: 79-81.
Fukao, T., Yamada, T., Tanabe, M., Terauchi, Y., Ota, T., Takayama, T., Asano, T., Takeuchi, T., Kadowaki, T., Hata Ji, J. and Koyasu, S. (2002) Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nat. Immunol. 3: 295-304.
Choi, Y. H., Yan, G. H., Chai, O. H., Lim, J. M., Sung, S. Y., Zhang, X., Kim, J. H., Choi, S. H., Lee, M. S., Han, E. H., Kim, H. T. and Song, C. H. (2006) Inhibition of anaphylaxis like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus. Biol. Pharm. Bull. 29:1360-1365.
Fukuishi, N., Sakaguchi, M., Matsuura, S., Nakagawa, C., Akagi, R. and Akagi, M. (1997) The mechanisms of compound 48/80-induced superoxide generation mediated by A-kinase in rat peritoneal mast cells. Biochem. Mol. Med. 61: 107-113.
Akagi, M., Katakuse, Y., Fukuishi, N., Kan, T. and Akagi, R. (1994) Superoxide anion-induced histamine release from rat peritoneal mast cells. Biol. Pharm. Bull. 17: 732-734.
Fukao, T., Yamada, T., Tanabe, M., Terauchi, Y., Ota, T., Takayama, T., Asano, T., Takeuchi, T., Kadowaki, T., Hata Ji, J. and Koyasu, S. (2002) Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nat. Immunol. 3: 295-304.
Choi, Y. H., Yan, G. H., Chai, O. H., Lim, J. M., Sung, S. Y., Zhang, X., Kim, J. H., Choi, S. H., Lee, M. S., Han, E. H., Kim, H. T. and Song, C. H. (2006) Inhibition of anaphylaxis like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus. Biol. Pharm. Bull. 29:1360-1365.
Fukuishi, N., Sakaguchi, M., Matsuura, S., Nakagawa, C., Akagi, R. and Akagi, M. (1997) The mechanisms of compound 48/80-induced superoxide generation mediated by A-kinase in rat peritoneal mast cells. Biochem. Mol. Med. 61: 107-113.
Akagi, M., Katakuse, Y., Fukuishi, N., Kan, T. and Akagi, R. (1994) Superoxide anion-induced histamine release from rat peritoneal mast cells. Biol. Pharm. Bull. 17: 732-734.
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