지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The function of mast cells as effector cells in allergy has been extensively studied. Mast cells activated through high affinity IgE-receptor (FcεRI) release diverse mediators, and lead to smooth muscle constriction, vasodilation, increase of vascular permeability, leukocyte recruitment and activation, mucus secretion, and tissue proliferation and remodeling. However, various other immunological and non-immunological signals can lead to the activation of mast cells. In resent years, mast cells have been identified to be involved in a complex range of immune functions. Mast cells can be important as key players in the regulation of innate as well as adapted immune responses, and may influence the development of allergy, autoimmune disorder and peripheral tolerance. This review summarizes the recent advances in the understanding of effector functions of mast cells in immune responses.
목차
서론
비만세포의 특성 및 비만세포 유래 매개물질
비만세포 기능 연구를 위한 생체 내(in vivo) 모델
비만세포 유래 단백질분해효소의 작용
내인성 및 외인성 독소에 대한 저항성
병원체에 대한 숙주의 방어반응에서의 기능
적응면역반응에서 비만세포의 기능
결론
감사의 글
References
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Agosti, V. / 2004 / Critical role for kit-mediated src kinase but not PI 3-kinase signaling in pro T and pro B cell development / J. Exp. Med 199 : 867 ~ 878
2. [학술지(정기간행물)] - Bischoff,S.C / 2007 / Role of mast cells in allergic and non-allergic immune responses: Comparison of human and murine data / Nat. Rev. Immunol 7 : 93 ~ 104
3. [학술지(정기간행물)] - Boesiger, J. / 1998 / Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression / J. Exp. Med 188 : 1135 ~ 1145
4. [학술지(정기간행물)] - Brown, J. M / 2008 / The mast cell and allergic diseases: Role in pathogenesis and implications for therapy / Clin. Exp. Allergy 38 : 4 ~ 18
5. [학술지(정기간행물)] - Bryce, P. J. / 2004 / Immune sensitization in the skin is enhanced by antigen-independent effects of IgE / Immunity 20 : 381 ~ 392
2. [학술지(정기간행물)] - Bischoff,S.C / 2007 / Role of mast cells in allergic and non-allergic immune responses: Comparison of human and murine data / Nat. Rev. Immunol 7 : 93 ~ 104
3. [학술지(정기간행물)] - Boesiger, J. / 1998 / Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression / J. Exp. Med 188 : 1135 ~ 1145
4. [학술지(정기간행물)] - Brown, J. M / 2008 / The mast cell and allergic diseases: Role in pathogenesis and implications for therapy / Clin. Exp. Allergy 38 : 4 ~ 18
5. [학술지(정기간행물)] - Bryce, P. J. / 2004 / Immune sensitization in the skin is enhanced by antigen-independent effects of IgE / Immunity 20 : 381 ~ 392
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UCI(KEPA) : I410-ECN-0101-2009-470-014816245