지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 22 - 29 (8page)
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초록· 키워드
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Background: Many inflammatory mediators, including various cytokines (e.g. interleukins and tumor necrosis factor [TNF]), inflammatory proteases, and histamine are released following mast cell activation. However, the endogenous modulators for mast cell activation and the underlying mechanism have yet to be elucidated. Endogenous cannabinoids such as palmitoylethanolamide (PEA) and N-arachidonoylethanolamine (anandamide or AEA), were found in peripheral tissues and have been proposed to possess autacoid activity, implying that cannabinoids may downregulate mast cell activation and local inflammation. Objective: In order to investigate the effect of cannabinoid receptor-1 (CB1R) agonists on mast cell activation, AEA-derived compounds were newly synthesized and evaluated for their effect on mast cell activation. Methods: The effects of selected compounds on FcRI-induced histamine and β-hexosaminidase release were evaluated in a rat basophilic leukemia cell line (RBL-2H3). To further investigate the inhibitory effects of CB1R agonist in vivo, an oxazolone-induced atopic dermatitis mouse model was exploited. Results: We found that CB1R inhibited the release of inflammatory mediators without causing cytotoxicity in RBL-2H3 cells and that CB1R agonists markedly and dose-dependently suppressed mast cell proliferation indicating that CB1R plays an important role in modulating antigen-dependent immunoglobulin E (IgE)-mediated mast cell activation. We also found that topical application of CB1R agonists suppressed the recruitment of mast cells into the skin and reduced the level of blood histamine.
Conclusion: Our results indicate that CB1R agonists downregulate mast cell activation and may be used for relieving inflammatory symptoms mediated by mast cell activation, such as atopic dermatitis, psoriasis, and contact dermatitis.
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참고문헌 (22)
참고문헌 신청
Gaoni Y. / 1964 / Isolation, structure, and partial synthesis of an active constituent of hashish / J Am Chem Soc 86:1646~1647
Pertwee RG / 1997 / Pharmacology of cannabinoid CB1 and CB2 receptors / Pharmacol Ther 74:129~180
Howlett AC. / 2002 / XXVII. Classification of cannabinoid receptors / Pharmacol Rev 54:161~202
Matsuda LA. / 1990 / Structure of a cannabinoid receptor and functional expression of the cloned cDNA / Nature 346:561~564
Munro S. / 1993 / Molecular characterization of a peripheral receptor for cannabinoids / Nature 365:61~65
Pertwee RG / 1997 / Pharmacology of cannabinoid CB1 and CB2 receptors / Pharmacol Ther 74:129~180
Howlett AC. / 2002 / XXVII. Classification of cannabinoid receptors / Pharmacol Rev 54:161~202
Matsuda LA. / 1990 / Structure of a cannabinoid receptor and functional expression of the cloned cDNA / Nature 346:561~564
Munro S. / 1993 / Molecular characterization of a peripheral receptor for cannabinoids / Nature 365:61~65
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