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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.12 No.2
- 발행연도
- 2022.5
- 수록면
- 197 - 203 (7page)
- DOI
- https://doi.org/10.1007/s13534-022-00219-x
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초록· 키워드
오류제보하기
Field effect transistor (FET) biosensor is based on metal oxide field effect transistor that is gated by changes in the surfacecharges induced the reaction of biomolecules. In most cases of FET biosensor, FET biosensor is not being reused after thereaction; therefore, it is an important concept of investigate the biosensor with simplicity, cheap and reusability. However,the conventional cardiac troponin I (cTnI) sensing technique is inadequate owing to its low sensitivity and high operationaltime and cost. In this study, we developed a rapid and low-cost, and disposable electrical sensor using an extended gatefield-effect transistor (EGFET) to detect cTnI, as a key biomarker for myocardiac infarction. We first investigated pH sensingcharacteristics according to the pH level, which provided a logarithmically linear sensitivity in the pH sensing buffer solutionof approximately 57.9 mV/pH. Subsequently, we prepared a cTnI sample and monitored the reaction between cTnI andcTnI antibodies through the changes in the drain current and transfer curves. Our results showed that the EGFET biosensorcould successfully detect the cTnI levels as well as the pH with low-cost and rapid detection.
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