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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제23권 제1호
- 발행연도
- 2019.1
- 수록면
- 17 - 26 (10page)
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We discuss recent advances in Gd-based T1-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm3. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.
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참고문헌 (37)
참고문헌 신청
Boron WF / 2008 / Medical physiology: a cellular and molecular approach / Saunders/Elsevier
Lambers H / 2006 / Natural skin surface pH is on average below 5, which is beneficial for its resident flora / Int J Cosmet Sci 28:359~370
Han J / 2010 / Fluorescent indicators for intracellular pH / Chem Rev 110:2709~2728
Adrogué HJ / 1994 / Blackwell’s basics of medicine / Blackwell Science :49~133
Vander Heiden MG / 2009 / Understanding the Warburg effect: the metabolic requirements of cell proliferation / Science 324:1029~1033
Lambers H / 2006 / Natural skin surface pH is on average below 5, which is beneficial for its resident flora / Int J Cosmet Sci 28:359~370
Han J / 2010 / Fluorescent indicators for intracellular pH / Chem Rev 110:2709~2728
Adrogué HJ / 1994 / Blackwell’s basics of medicine / Blackwell Science :49~133
Vander Heiden MG / 2009 / Understanding the Warburg effect: the metabolic requirements of cell proliferation / Science 324:1029~1033
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