Protection of Skin Fibroblasts from Infrared-A-Induced Photo-Damage Using Ginsenoside Rg3(S)-Incorporated Soybean Lecithin Liposomes

Jung Won Ho; Song Jihyeon; You Gayeon; Lee Jun Hyuk; Lee Sin Won; Ahn Joong-Hoon; Mok Hyejung

doi:10.4014/jmb.2210.10048

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자료유형: 학술저널

저자정보: Jung Won Ho (Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea) Song Jihyeon (Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea) You Gayeon (Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea) Lee Jun Hyuk (Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea) Lee Sin Won (Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea) Ahn Joong-Hoon (Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea) Mok Hyejung (Department of Bioscience and Biotechnology Konkuk University Seoul 05029 Republic of Korea)

저널정보: 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제33권 제1호

발행연도: 2023.1

수록면: 135 - 141 (7page)

DOI: 10.4014/jmb.2210.10048

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Protection of skin cells from chronic infrared-A (IRA) irradiation is crucial for anti-photoaging of the skin. In this study, we investigated the protective activity of Rg3(S) and Rg3(S)-incorporated anionic soybean lecithin liposomes (Rg3/Lipo) with a size of approximately 150 nm against IRA-induced photodamage in human fibroblasts. The formulated Rg3/Lipo showed increased solubility in aqueous solution up to a concentration of 200 μg/ml, compared to free Rg3(S). In addition, Rg3/Lipo exhibited superior colloidal stability in aqueous solutions and biocompatibility for normal human dermal fibroblasts (NHDFs). After repeated IRA irradiation on NHDFs, elevated levels of cellular and mitochondrial reactive oxygen species (ROS) were greatly reduced by Rg3(S) and Rg3/Lipo. In addition, cells treated with Rg3/Lipo exhibited noticeably reduced apoptotic signals following IRA irradiation compared to untreated cells. Thus, considering aqueous solubility and cellular responses, Rg3/Lipo could serve as a promising infrared protector for healthy aging of skin cells.

#Rg3(S) #soybean lecithin liposome #fibroblast #infrared-A #photo-damage

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