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Ginsenoside Rg4 enhances the inductive effects of human dermal papilla spheres on hair growth via the AKT/GSK-3β/β-catenin signaling pathway
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논문 기본 정보

Type
Academic journal
Author
Yun Hee Lee (건국대학교) Hui-Ji Choi (충남대학교) Ji Yea Kim (건국대학교 화장품공학과 질병분자표적신약연구소) Kim Ji-Eun (충남대학교) Jee-Hyun Lee (충남대학교) So-Hyun Cho (충남대학교) yun mi young (광주여자대학교) Sungkwan An (건국대학교) Song Gyu-Yong (충남대학교) Bae Seunghee (건국대학교)
Journal
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제7호 KCI Accredited Journals SCOPUS
Published
2021.1
Pages
933 - 941 (9page)

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Ginsenoside Rg4 enhances the inductive effects of human dermal papilla spheres on hair growth via the AKT/GSK-3β/β-catenin signaling pathway
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Ginsenoside Rg4 is a rare ginsenoside that is naturally found in ginseng, and exhibits a wide range of biological activities including antioxidant and anti-inflammatory properties in several cell types. The purpose of this study was to use an in vivo model of hair follicle (HF)-mimic based on a human dermal papilla (DP) spheroid system prepared by three-dimensional (3D) culture and to investigate the effect of Rg4 on the hair-inductive properties of DP cells. Treatment of the DP spheroids with Rg4 (20 to 50 μg/ml) significantly increased the viability and size of the DP spheres in a dose-dependent manner. Rg4 also increased the mRNA and protein expression of DP signature genes that are related to hair growth including ALP, BMP2, and VCAN in the DP spheres. Analysis of the signaling molecules and luciferase reporter assays further revealed that Rg4 induces the activation of phosphoinositide 3-kinase (PI3K)/AKT and the inhibitory phosphorylation of GSK3β, which activates the WNT/β- catenin signaling pathway. These results correlated with not only the increased nuclear translocation of β-catenin following the treatment of the DP spheres with Rg4 but also the significant elevation of mRNA expression of the downstream target genes of the WNT/β-catenin pathway including WNT5A, β-catenin, and LEF1. In conclusion, these results demonstrated that ginsenoside Rg4 promotes the hair-inductive properties of DP cells by activating the AKT/GSK3β/β- catenin signaling pathway in DP spheres, suggesting that Rg4 could be a potential natural therapy for hair growth.
#Ginsenoside Rg4 #hair growth property #dermal papilla #AKT #β-catenin

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