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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제1호
- 발행연도
- 2020.1
- 수록면
- 101 - 108 (8page)
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Infections by herpes simplex viruses have an immense impact on humans, ranging from selflimiting, benign illness to serious, life-threatening diseases. While nucleoside analog drugs are available, resistance has been increasing and currently no vaccine exists. Ginsenosides derived from Panax ginseng have been documented to inhibit several viruses and bolster immune defenses. This study evaluated 12 of the most relevant ginsenosides from P. ginseng for toxicities and inhibition of herpes simplex viruses types 1 and 2 in Vero cells. The effects of test compounds and virus infection were determined using a PrestoBlue cell viability assay. Time course studies were also conducted to better understand at what points the virus life cycle was affected. Non-toxic concentrations of the ginsenosides were determined and ranged from 12.5 μM to greater than 100 μM. Ginsenoside 20(S)-Rg3 demonstrated the greatest inhibitory effect and was active against both HSV-1 and HSV-2 with an IC50 of approximately 35 μM. The most dramatic inhibition—over 100% compared to controls—occurred when the virus was exposed to 20(S)-Rg3 for 4 h prior to being added to cells. 20(S)-Rg3 holds promise as a potential chemotherapeutic agent against herpes simplex viruses and, when used together with valacyclovir, may prevent increased resistance to drugs.
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참고문헌 (35)
참고문헌 신청
Faral-Tello P / 2012 / Cytotoxic, virucidal, and antiviral activity of South American plant and algae extracts / Sci. World J 2012:174837
Bookstaver PB / 2017 / Management of viral central nervous system infections : a primer for clinicians / J. Cent. Nerv. Syst. Dis 9:1~12
Hogestyn JM / 2018 / Contributions of neurotropic human herpesviruses herpes simplex 1 and human herpesvirus 6 to neurodegenerative disease pathology / Neural. Regen. Res 13:211~221
Koelle DM / 2006 / Vaccines for herpes simplex virus infections / Curr. Opin. Investig. Drugs 7:136~141
Akhtar J / 2009 / Viral entry mechanisms : cellular and viral mediators of herpes simplex virus entry / FEBS J 276:7228~7236
Bookstaver PB / 2017 / Management of viral central nervous system infections : a primer for clinicians / J. Cent. Nerv. Syst. Dis 9:1~12
Hogestyn JM / 2018 / Contributions of neurotropic human herpesviruses herpes simplex 1 and human herpesvirus 6 to neurodegenerative disease pathology / Neural. Regen. Res 13:211~221
Koelle DM / 2006 / Vaccines for herpes simplex virus infections / Curr. Opin. Investig. Drugs 7:136~141
Akhtar J / 2009 / Viral entry mechanisms : cellular and viral mediators of herpes simplex virus entry / FEBS J 276:7228~7236
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