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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제4호
- 발행연도
- 2016.1
- 수록면
- 775 - 783 (9page)
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초록· 키워드
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The identification of novel reagents that exert a biological ultraviolet (UV)-protective effect in skin cells represents an important strategy for preventing UV-induced skin aging. To this end, we investigated the potential protective effects of Ettlia sp. YC001 extracts against UV-induced cellular damage in normal human dermal fibroblasts (NHDFs). We generated four different extracts from Ettlia sp. YC001, and found that they exhibit low cytotoxicity in NHDFs. The ethyl acetate extract of Ettlia sp. YC001 markedly decreased UVB-induced cytotoxicity. Additionally, the ethyl acetate extract significantly inhibited the production of hydrogen peroxide-induced reactive oxygen species. Moreover, it inhibited UVB-induced thymine dimers, as confirmed by luciferase assay and thymine dimer dot-blot assay. Thus, the study findings suggest Ettlia sp. YC001 extract as a novel photoprotective reagent on UVB-induced cell dysfunctions in NHDFs.
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참고문헌 (26)
참고문헌 신청
Al Mahroos M / 2002 / Effect of sunscreen applcation on UV-induced thymine dimers / Arch. Dermatol 138:1480~1485
Amorim-Carrilho KT / 2014 / Review of methods for analysis of carotenoids / TRAC Trends Anal. Chem 56:49~73
An IS / 2012 / Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts / Int. J. Mol. Med 30:1194~1202
Bae S / 2015 / Low-dose gamma-irradiation induces dual radio-adaptive responses depending on the post-irradiation time by altering microRNA expression profiles in normal human dermal fibroblasts / Int. J. Mol. Med 35:227~237
Emami K / 2015 / Proteomic-based biotyping reveals hidden diversity within a microalgae culture collection: an example using Dunaliella / Sci. Rep 5:10036
Amorim-Carrilho KT / 2014 / Review of methods for analysis of carotenoids / TRAC Trends Anal. Chem 56:49~73
An IS / 2012 / Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts / Int. J. Mol. Med 30:1194~1202
Bae S / 2015 / Low-dose gamma-irradiation induces dual radio-adaptive responses depending on the post-irradiation time by altering microRNA expression profiles in normal human dermal fibroblasts / Int. J. Mol. Med 35:227~237
Emami K / 2015 / Proteomic-based biotyping reveals hidden diversity within a microalgae culture collection: an example using Dunaliella / Sci. Rep 5:10036
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