지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 104 - 137 (34page)
- DOI
- 10.20307/nps.2023.29.2.104
이용수
초록· 키워드
오류제보하기
COVID-19 caused a catastrophe in human health. People infected with COVID-19 also suffer from various clinical illnesses during and after the infection. The Boerhavia diffusa plant is well known for its antihypertensive activity. ACE-II inhibitors and calcium channel blockers are reported as mechanisms for the antihypertensive activity of B. diffusa phytoconstituents. Various studies have said ACE-II is the virus"s binding site to attack host cells. COVID-19 treatment commonly employs a variety of synthetic antiviral and steroidal drugs. As a result, other clinical illnesses, such as hypertension and hyperglycemia, emerge as serious complications. Safe and effective drug delivery is a prime objective of the drug development process. COVID-19 is treated with various herbal treatments; however, they are not widely used due to their low potency. Many herbal plants and formulations are used to treat COVID-19 infection, in which B. diffusa is the most widely used plant. The current study relies on discovering active phytoconstituents with ACE-II inhibitory activity in the B. diffusa plant. As a result, it can be used as a treatment option for patients with COVID-19 and related diseases. Different phytoconstituents of the B. diffusa plant were selected from the reported literature. The activity of phytoconstituents against ACE-II proteins has been studied. Molecular docking and ligand-protein interaction computation tools are used in the in-silico experiment. Physicochemical, drug-likeness, water solubility, lipophilicity, and pharmacokinetic parameters are used to evaluate phytoconstituents. Liriodenine has the best drug-likeness, bioactivity, and binding score characteristics among the selected ligands. The in-silico study aims to find the therapeutic potential of B. diffusa phytoconstituents against ACE-II. Targeting ACE-II also shows an effect against SARS-CoV-2. It can serve as a rationale for designing a drug for patient infected with COVID-19 and associated diseases.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms
Clinical Hypertension
2020 .01
-
코로나바이러스19 감염증과 안지오텐신전환효소2
대한내과학회지
2020 .08
-
백화사설초 추출물의 인체 대장암 세포주에서 항암효능에 관한 연구
대한한의학방제학회지
2015 .01
-
Exposure to Adverse Childhood Experiences (ACEs) and Stress among the Community-based Urban Pediatric Population in Korea
Journal of Korean Medical Science
2020 .01
-
Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19
Annals of Laboratory Medicine
2021 .01
-
Comparing the safety of harmonic ACE and ACE+ around the recurrent laryngeal nerve in swine models
Annals of Surgical Treatment and Research
2018 .06
-
COVID-19
International Neurourology Journal
2020 .01
-
합환피 추출물의 지방세포 분화 억제 효과
동의생리병리학회지
2016 .12
-
An overview of the gut side of the SARS-CoV-2 infection
Intestinal research
2021 .10
-
COVID-19 drugs: potential interaction with ATP-binding cassette transporters P-glycoprotein and breast cancer resistance protein
Journal of Pharmaceutical Investigation
2023 .03
-
코로나바이러스감염증-19 치료제 현황
보건의료기술평가
2020 .01
-
Recombinant ACE2-Ig Fusion Protein Neutralizes SARS-CoV-2
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .03
-
[우수신진연구자 발표 1] Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?
Clinical Hypertension
2020 .01
-
Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID
Infection and Chemotherapy
2024 .03
-
The Thai Version of the Addenbrooke’s Cognitive Examination III
PSYCHIATRY INVESTIGATION
2016 .01
-
Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval
Journal of Korean Medical Science
2024 .04
-
Lack of Influence of the ACE1 Gene I/D Polymorphism on the Formation and Growth of Benign Uterine Leiomyoma in Turkish Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The Impact of Maternal Adverse Childhood Experiences on Offspring’s Internalizing and Externalizing Problems
PSYCHIATRY INVESTIGATION
2021 .11
-
Ethanol Extract of Oldenlandia diffusa – an Effective Chemotherapeutic for the Treatment of Colorectal Cancer in Humans -Anti-Cancer Effects of Oldenlandia diffusa-
Journal of Pharmacopuncture
2016 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Effects of Horsetail, Alfalfa, Ortie, Chêne and Aleppo oak as Potential Hemostatic Agents on Laboratory Coagulation Tests
Sina Ahmadianfa
,
Nahid Meh
,
abi
외 7명
Natural Product Sciences
2023
.03
Xanthones and 4-Phenylcoumarins from the Twigs of Mesua beccariana (Baill.) Kosterm
Mulyadi Tanjung
,
Tjitjik S
,
ie Tjahjanda
외 11명
Natural Product Sciences
2023
.03
Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling
Hui-Ju Lee
,
Geum-Lan Hong
,
Kyung-Hyun Kim
외 3명
Natural Product Sciences
2023
.03
Total Phenolic Content and Antioxidant Activities of Leaves and Bark Extract of Adenanthera pavonina L.
Agustin Yumita
,
Endang Hanani
,
Anis Agustina
외 5명
Natural Product Sciences
2023
.03
Meliasendanins E-J, Nor-neolignan Constituents from Melia toosendan and their Anti-inflammatory Activity
Jin Woo Lee
Natural Product Sciences
2023
.03
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0102-2023-518-001743287