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논문 기본 정보

자료유형
학술저널
저자정보
Sina Ahmadianfar (Shahid Chamran University of Ahvaz) Nahid Mehrabi (Aja University of Medical Sciences) Saeed Mohammadi (Tehran University of Medical Sciences) Ali Sobhanizadeh (University of Mohaghegh Ardabili) Alireza Moradabadi (Khomein university of medical sciences) Ali Noroozi-Aghideh (Aja University of Medical Sciences)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.29 No.1
발행연도
2023.3
수록면
42 - 49 (8page)
DOI
10.20307/nps.2023.29.1.42

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초록· 키워드

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This study investigated the effect of ethanol extracts of horsetail, alfalfa, ortie, chêne and aleppo oak on blood coagulation in vitro. Extraction was performed by the maceration method. Extracts were mixed with platelet and plasma, then prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet aggregation tests were conducted. Alfalfa extract had a dose-dependent effect on the PT. Ortie, and horsetail, reduced the PT significantly compared to control group. Alfalfa, horsetail, and ortie reduced the APTT, but their effect was insignificant compared to the control group. The pooled extract showed the highest effect compared to the single extracts in a dose-dependent manner. Horsetail and alfalfa induced platelet aggregation in response to arachidonic acid but not in response to collagen. In the case of ortie, no aggregation occurred regarding the arachidonic acid, and incomplete was observed in response to collagen. Interestingly, blood clotting occurred immediately after adding the chêne, aleppo oak and the pooled extract, and therefore platelet poor plasma (PPP) and platelet rich plasma (PRP) became jelly. Generally, chêne and aleppo oak, as well as pooled extract, were more effective in inducing both primary and secondary coagulation pathways via shortening the PT and APTT, and induction of platelet aggregation.

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Abstract
Introduction
Experimental
Results
Discussion
References

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