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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 26 - 30 (5page)
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초록· 키워드
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Abstract Antihypertensive drugs are one of the most widely used pharmacologic agent in the world and it is predominantly used in the elderly subjects. Pneumonia is the most common cause of death in the extremely old subject. During infection and its complication such as sepsis, hypotension could be exacerbated by antihypertensive drugs because homeostasis mechanisms such as sodium balance, renin angiotensin aldosterone system and/or sympathetic nervous system can be mitigated by antihypertensive drug therapy. Severe Acute Respiratory Syndrome-Coronavirus-1 and 2 viral surface protein is known to attach angiotensin converting enzyme 2 (ACE2) on the cell membrane to facilitate viral entry into the cytoplasm. Despite the theoretical concerns of increased ACE2 expression by Renin-AngiotensinAldosterone system (RAS) blockade, there is no evidence that RAS inhibitors are harmful during COVID-19 infection and have in fact been shown to be beneficial in animal studies. Therefore, it is recommended to maintain RAS blockade during the current corona virus pandemic.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Hsu WT / 2020 / Effect of reninangiotensin-aldosterone system inhibitors on short-term mortality after Sepsis : a population-based cohort study / Hypertension 75:483~491
Hsu CT / 2020 / Depressed sympathovagal modulation indicates sepsis in patients with suspected infection / Medicine(Baltimore) 99:e18961
Gilstrap LG / 2017 / Initiation, continuation, or withdrawal of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and outcomes in patients hospitalized with heart failure with reduced ejection fraction / J Am Heart Assoc 6
Prins KW / 2015 / Effects of Beta-blocker withdrawal in acute decompensated heart failure : a systematic review and meta-analysis / JACC Heart Fail 3:647~653
Ohkubo T / 2004 / Effects of an angiotensin-converting enzyme inhibitor-based regimen on pneumonia risk / Am J Respir Crit Care Med 169:1041~1045
Hsu CT / 2020 / Depressed sympathovagal modulation indicates sepsis in patients with suspected infection / Medicine(Baltimore) 99:e18961
Gilstrap LG / 2017 / Initiation, continuation, or withdrawal of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and outcomes in patients hospitalized with heart failure with reduced ejection fraction / J Am Heart Assoc 6
Prins KW / 2015 / Effects of Beta-blocker withdrawal in acute decompensated heart failure : a systematic review and meta-analysis / JACC Heart Fail 3:647~653
Ohkubo T / 2004 / Effects of an angiotensin-converting enzyme inhibitor-based regimen on pneumonia risk / Am J Respir Crit Care Med 169:1041~1045
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