Might simple peripheral blood parameters be an early indicator in the prediction of severity and morbidity of cholecystitis?

Sevda Yilmaz; Muhammed Rasid Aykota; Utku Ozgen; Onur Birsen; Selda Simsek; Burhan Kabay

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저자정보: Sevda Yilmaz (Pamukkale University Faculty of Medicine) Muhammed Rasid Aykota (Pamukkale University Faculty of Medicine) Utku Ozgen (Pamukkale University Faculty of Medicine) Onur Birsen (Pamukkale University Faculty of Medicine) Selda Simsek (Pamukkale University Faculty of Medicine) Burhan Kabay (Pamukkale University Faculty of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.104 No.6

발행연도: 2023.6

수록면: 332 - 338 (7page)

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Purpose: The aim of this study is to examine the effectiveness of the neutrophil-lymphocyte ratio (NLR) and CRP/albumin ratio (CAR) in evaluating disease severity and predicting clinical outcomes in patients diagnosed with acute cholecystitis (AC).
Methods: A total of 186 patients with AC were evaluated retrospectively. NLR, CAR, Mannheim Peritonitis Index (MPI), and P-POSSUM (Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity) scores were compared with AC severity grade.
Results: The rates of the grade 1 patients (group 1) and the grade 2–3 patients (group 2) were 57.5% (n = 107) and 42.5% (n = 79) according to the disease severity according to Tokyo Guidelines criteria (TG) 18/TG13, respectively. The morbidity rates determined in groups 1 and 2 were 26.7% (n = 28) and 51.9% (n = 41), respectively. No mortality was found in group 1, whereas the mortality rate in group 2 was 6.3% (n = 5). According to multivariate analysis, CAR (odds ratio [OR], 1.234; P ＜ 0.001) and MPI (OR, 1.175; P = 0.001) were found to be associated with moderate-severe disease while CAR (OR, 1.109; P = 0.035) and P-POSSUM morbidity (OR, 1.063; P = 0.007) variables were found to be associated with the presence of morbidity.
Conclusion: We have demonstrated that CAR can be used in predicting severity of AC and that CAR is an alternative simple parameter of P-POSSUM morbidity score in prediction of morbidity in these cases. In addition to other assessment methods, these scores can provide valuable and complementary information in assessment of disease severity and prognosis in AC.

#Acute cholecystitis #Albumins #C-reactive protein #Neutrophil-lymphocyte ratio

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