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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Microprocessor is an RNase III enzyme complex that recognizes long RNA stem-loop structures and cleaves doublestrandedRNAs. It is comprised of a catalytic subunit DROSHA and a dimeric RNA-binding cofactor DGCR8 (DiGeorgeSyndrome Critical Region 8). The most pronounced function of the protein complex is to process primary microRNAs(pri-miRNAs) in nucleus for initiating microRNA biogenesis. Since this step plays a critical role in determining the miRNAseed sequence that base-pairs with its target mRNAs for silencing, the cleavage sites on pri-miRNAs must be preciselyselected. Microprocessor recognizes several pri-miRNA features, including double-stranded RNA?single-stranded RNAjunctions, for determining the substrate binding orientation and finding the correct cleavage sites. Structural studies on anumber of RNase III proteins have shown various mechanisms used for the precise selection of the cleavage sites, whichare useful to understand those involved in Microprocessor. Recent biochemical and systematic mutational studies onhuman Microprocessor provide deep insights into the processing mechanisms and open up many interesting questions tobe addressed by future structural studies.
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참고문헌 (61)
참고문헌 신청
Abou Elela, S. / 1998 / Depletion of yeast RNase III blocks correct U2 3' end formation and results in polyadenylated but functional U2 snRNA / EMBO J 17:3738~3746
Auyeung, V. C. / 2013 / Beyond secondary structure : primary-sequence determinants license pri-miRNA hairpins for processing / Cell 152:844~858
Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Bohnsack, M. T. / 2004 / Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs / RNA 10:185~191
Burke J. M. / 2014 / A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA / RNA 20:1068~1077
Auyeung, V. C. / 2013 / Beyond secondary structure : primary-sequence determinants license pri-miRNA hairpins for processing / Cell 152:844~858
Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Bohnsack, M. T. / 2004 / Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs / RNA 10:185~191
Burke J. M. / 2014 / A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA / RNA 20:1068~1077
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