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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제1호
- 발행연도
- 2016.1
- 수록면
- 25 - 33 (9page)
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Ion channels in carcinoma and their roles in cell proliferation are drawing attention. Intracellular Ca2+ ([Ca2+]i)-dependent signaling affects the fate of cancer cells. Here we investigate the role of Ca2+-activated K+ channel (SK4) in head and neck squamous cell carcinoma cells (HNSCCs) of dif-ferent cell lines; SNU-1076, OSC-19 and HN5. Treatment with 1 μM ionomycin induced cell death in all the three cell lines. Whole-cell patch clamp study suggested common expressions of Ca2+-activated Cl? channels (Ano-1) and Ca2+-activated nonselective cation channels (CAN). 1-EBIO, an activator of SK4, induced outward K+ current (ISK4) in SNU-1076 and OSC-19. In HN5, ISK4 was not observed or negligible. The 1-EBIO-induced current was abolished by TRAM-34, a selective SK4 blocker. Interestingly, the ionomycin-induced cell death was effectively prevented by 1-EBIO in SNU-1076 and OSC-19, and the rescue effect was annihilated by combined TRAM-34. Con-sistent with the lower level of ISK4, the rescue by 1-EBIO was least effective in HN5. The results newly demonstrate the role of SK4 in the fate of HNSCCs under the Ca2+ overloaded condition. Pharmacological modulation of SK4 might provide an intriguing novel tool for the anti-cancer strategy in HNSCC.
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참고문헌 (36)
참고문헌 신청
Lim Y / 2013 / Clinical outcomes of radiation-based locoregional therapy in locally advanced head and neck squamous cell carcinoma patients not responding to induction chemotherapy / Oral Surg Oral Med Oral Pathol Oral Radiol 116:55~60
Huber SM. / 2013 / Oncochannels / Cell Calcium 53:241~255
Ge L / 2014 / Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy / Int Immunopharmacol 22:427~443
Stocker M. / 2004 / Ca2+-activated K+ channels: molecular determinants and function of the SK family / Nat Rev Neurosci 5:758~770
Launay P / 2002 / TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization / Cell 109:397~407
Huber SM. / 2013 / Oncochannels / Cell Calcium 53:241~255
Ge L / 2014 / Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy / Int Immunopharmacol 22:427~443
Stocker M. / 2004 / Ca2+-activated K+ channels: molecular determinants and function of the SK family / Nat Rev Neurosci 5:758~770
Launay P / 2002 / TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization / Cell 109:397~407
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