지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 738 - 752 (15page)
이용수
초록· 키워드
오류제보하기
Purpose The purpose of this study is to determine whether luminacin, a marine microbial extract from the Streptomyces species, has anti-tumor effects on head and neck squamous cell carcinoma (HNSCC) cell lines via autophagic cell death.
Materials and Methods Inhibition of cell survival and increased cell death was measured using cell viability, colony forming, and apoptosis assays. Migration and invasion abilities of head and cancer cells were evaluated using wound healing, scattering, and invasion assays. Changes in the signal pathway related to autophagic cell death were investigated. Drug toxicity of luminacin was examined in in vitro HaCaT cells and an in vivo zebrafish model.
Results Luminacin showed potent cytotoxicity in HNSCC cells in cell viability, colony forming, and fluorescence-activated cell sorting analysis. In vitro migration and invasion of HNSCC cells were attenuated by luminacin treatment. Combined with Beclin-1 and LC3B, Luminacin induced autophagic cell death in head and neck cancer cells. In addition, in a zebrafish model and human keratinocyte cell line used for toxicity testing, luminacin treatment with a cytotoxic concentration to HNSCC cells did not cause toxicity.
Conclusion Taken together, these results demonstrate that luminacin induces the inhibition of growth and cancer progression via autophagic cell death in HNSCC cell lines, indicating a possible alternative chemotherapeutic approach for treatment of HNSCC.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
정규원 / 2014 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011 / Cancer Research and Treatment 46(2):109~123
Takes RP / 2012 / Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects / Oral Oncol 48:775~779
Newman DJ / 2012 / Natural products as sources of new drugs over the 30 years from 1981 to 2010 / J Nat Prod 75:311~335
Gerwick WH / 2012 / Lessons from the past and charting the future of marine natural products drug discovery and chemical biology / Chem Biol 19:85~98
Shin HA / 2014 / Radioprotective effect of epicatechin in cultured human fibroblasts and zebrafish / J Radiat Res 55:32~40
Takes RP / 2012 / Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects / Oral Oncol 48:775~779
Newman DJ / 2012 / Natural products as sources of new drugs over the 30 years from 1981 to 2010 / J Nat Prod 75:311~335
Gerwick WH / 2012 / Lessons from the past and charting the future of marine natural products drug discovery and chemical biology / Chem Biol 19:85~98
Shin HA / 2014 / Radioprotective effect of epicatechin in cultured human fibroblasts and zebrafish / J Radiat Res 55:32~40
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
두경부편평세포암에서의 T세포 면역치료
대한 두경부 종양 학술지
2017 .01
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
VEGFR2 Expression in Head and Neck Squamous Cell Carcinoma Cancer Cells Mediates Proliferation and Invasion
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Head and Neck Squamous Cell Carcinoma - Comparative Evaluation of Pathological Parameters in Young and Old Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Immunotherapy in Head and Neck Squamous Cell Cancer
Clinical and Experimental Otorhinolaryngology
2018 .01
-
Cell Death and Liver Disease
Gut and Liver
2020 .01
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
두경부암에서 MicroRNA의 진단적 및 치료적 역할
대한이비인후-두경부외과학회지
2022 .02
-
Association Between Interleukin-6 and Head and Neck Squamous Cell Carcinoma: A Systematic Review
Clinical and Experimental Otorhinolaryngology
2021 .01
-
Heterogeneity of Islet Cells during Embryogenesis and Differentiation
Diabetes and Metabolism Journal
2023 .03
-
Aqueous Extract of Anticancer Drug CRUEL Herbomineral Formulation Capsules Exerts Anti-proliferative Effects in Renal Cell Carcinoma Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Role of PD-1 expressed on regulatory T cells during cancer progression
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential
생체재료학회지
2023 .03
-
Activation of K+ channel by 1-EBIO rescues the head and neck squamous cell carcinoma cells from Ca2+ ionophore-induced cell death
The Korean Journal of Physiology & Pharmacology
2016 .01
-
유방암 줄기세포 개념 및 제한점
의생명과학
2018 .01
-
Anticancer Drugs at Low Concentrations Upregulate the Activity of Natural Killer Cell
대한의생명과학회지
2023 .09
-
Research on Epstein-Barr virus immunity using a mouse model: from new insights to cancer immunotherapeutic applications
한국실험동물학회 학술발표대회 논문집
2022 .01
-
두경부암에서의 상피-간엽이행
대한이비인후-두경부외과학회지
2020 .01
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0