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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 176 - 183 (8page)
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Oral squamous cell carcinoma (OSCC) metastasis is characterized by distant metastasis and local recurrence.
Combined chemotherapy with cisplatin and 5-fluorouracil is routinely used to treat patients with OSCC, and the combined use of gefitinib with cytotoxic drugs has been reported to enhance the sensitivity of cancer cells in vitro .
However, the development of drug resistance because of prolonged chemotherapy is inevitable, leading to a poor prognosis. Therefore, understanding alterations in signaling pathways and gene expression is crucial for overcoming the development of drug resistance. However, the altered characterization of Ca2+ signaling in drug-resistant OSCC cells remains unclear. In this study, we investigated alterations in intracellular Ca2+ ([Ca2+]i) mobilization upon the development of gefitinib resistance in human tongue squamous carcinoma cell line (HSC)-3 and HSC-4 using ratiometric analysis. This study demonstrated the presence of altered epidermal growth factor- and purinergic agonist-mediated [Ca2+]i mobilization in gefitinib-resistant OSCC cells. Moreover, Ca2+ content in the endoplasmic reticulum, store-operated calcium entry, and lysosomal Ca2+ release through the transient receptor potential mucolipin 1, were confirmed to be significantly reduced upon the development of apoptosis resistance. Consistent with [Ca2+]i mobilization, we identified modified expression levels of Ca2+ signaling-related genes in gefitinib-resistant cells. Taken together, we propose that the regulation of [Ca2+]i mobilization and related gene expression can be a new strategy to overcome drug resistance in patients with cancer.
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참고문헌 (24)
참고문헌 신청
Di Gennaro E / 2003 / Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 (‘Iressa’), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells / J Cell Physiol 195:139~150
Khalil A / 2017 / The EGFR inhibitor gefitinib enhanced the response of human oral squamous cell carcinoma to cisplatin in vitro / Drugs R D 17:545~555
Cohen EE / 2003 / Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck / J Clin Oncol 21:1980~1987
Zhang P / 2006 / Identification of genes associated with cisplatin resistance in human oral squamous cell carcinoma cell line / BMC Cancer 6:224
Monteith GR / 2012 / Calcium channels and pumps in cancer : changes and consequences / J Biol Chem 287:31666~31673
Khalil A / 2017 / The EGFR inhibitor gefitinib enhanced the response of human oral squamous cell carcinoma to cisplatin in vitro / Drugs R D 17:545~555
Cohen EE / 2003 / Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck / J Clin Oncol 21:1980~1987
Zhang P / 2006 / Identification of genes associated with cisplatin resistance in human oral squamous cell carcinoma cell line / BMC Cancer 6:224
Monteith GR / 2012 / Calcium channels and pumps in cancer : changes and consequences / J Biol Chem 287:31666~31673
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