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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 699 - 704 (6page)
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초록· 키워드
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Developmentally regulated GTP-binding protein 2 (DRG2) plays an important role in cell growth. Here we explored the linkage between DRG2 and G2/M phase checkpoint function in cell cycle progression. We observed that knockdown of DRG2 in HeLa cells affected growth in a wound-healing assay, and tumorigenicity in nude mice xenografts. Flow cytometry assays and [3H] incorporation assays indicated that G2/M phase arrest was responsible for the decreased proliferation of these cells. Knockdown of DRG2 elicited down-regulation of the major mitotic promoting factor, the cyclin B1/Cdk1 complex, but up-regulation of the cell cycle arresting proteins, Wee1, Myt1, and p21. These findings identify a novel role of DRG2 in G2/M progression.
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참고문헌 (14)
참고문헌 신청
Baldin, V. / 1995 / Subcellular localisation of human wee1 kinase is regulated during the cell cycle / J. Cell Sci 108(Pt 6):2425~2432
Besson, A. / 2008 / CDK inhibitors : cell cycle regulators and beyond / Dev. Cell 14:159~169
Cazzalini, O. / 2010 / Multiple roles of the cell cycle inhibitor p21(CDKN1A)in the DNA damage response / Mutat. Res 704:12~20
Charrier-Savournin, F. B. / 2004 / p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress / Mol. Biol Cell 15:3965~3976
Fisher, D. / 2012 / Phosphorylation network dynamics in the control of cell cycle transitions / J. Cell Sci 125:4703~4711
Besson, A. / 2008 / CDK inhibitors : cell cycle regulators and beyond / Dev. Cell 14:159~169
Cazzalini, O. / 2010 / Multiple roles of the cell cycle inhibitor p21(CDKN1A)in the DNA damage response / Mutat. Res 704:12~20
Charrier-Savournin, F. B. / 2004 / p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress / Mol. Biol Cell 15:3965~3976
Fisher, D. / 2012 / Phosphorylation network dynamics in the control of cell cycle transitions / J. Cell Sci 125:4703~4711
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