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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 1,045 - 1,051 (7page)
- DOI
- 10.14348/molcells.2018.0129
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초록· 키워드
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The developmentally regulated GTP binding protein 2 (DRG2) is involved in the control of cell growth and differentiation. Here, we demonstrate that DRG2 regulates microtubule dynamics in HeLa cells. Analysis of live imaging of the plus-ends of microtubules with EB1-EGFP showed that DRG2 deficiency (shDRG2) significantly reduced the growth rate of HeLa cells. Depletion of DRG2 increased ‘slow and long-lived’ subpopulations, but decreased ‘fast and short-lived’ subpopulations of microtubules. Microtubule polymerization inhibitor exhibited a reduced response in shDRG2 cells. Using immunoprecipitation, we show that DRG2 interacts with tau, which regulates microtubule polymerization. Collectively, these data demonstrate that DRG2 may aid in affecting microtubule dynamics in HeLa cells.
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참고문헌 (22)
참고문헌 신청
Akhmanova, A. / 2008 / Tracking the ends: a dynamic protein network controls the fate of microtubule tips / Nat. Rev. Mol. Cell Biol 9:309~322
Amos, L. A. / 1999 / How taxol stabilises microtubule structure / Chem. Biol 6:R65~R69
Applegate, K. T. / 2011 / plusTipTracker: Quantitative image analysis software for the measurement of microtubule dynamics / J. Struct. Biol 176:168~184
Braun, A. / 2014 / Rac1 and aurora a regulate MCAK to polarize microtubule growth in migrating endothelial cells / J. Cell Biol 206:97~112
Desai, A. / 1997 / Microtubule polymerization dynamics / Annu Rev. Cell Dev. Biol 13:83~117
Amos, L. A. / 1999 / How taxol stabilises microtubule structure / Chem. Biol 6:R65~R69
Applegate, K. T. / 2011 / plusTipTracker: Quantitative image analysis software for the measurement of microtubule dynamics / J. Struct. Biol 176:168~184
Braun, A. / 2014 / Rac1 and aurora a regulate MCAK to polarize microtubule growth in migrating endothelial cells / J. Cell Biol 206:97~112
Desai, A. / 1997 / Microtubule polymerization dynamics / Annu Rev. Cell Dev. Biol 13:83~117
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