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Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis
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논문 기본 정보

Type
Academic journal
Author
Journal
한국미생물생명공학회 한국미생물·생명공학회지 한국미생물·생명공학회지 제47권 제1호 KCI Accredited Journals
Published
2019.1
Pages
34 - 42 (9page)

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Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis
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Apigenin, a common natural product that is found in many plants and vegetables, has been reported to have many biological activities, including antioxidative, anti-inflammatory, and anticancer effects. The triple- negative breast carcinoma cell line MDA-MB-231 is known to be highly invasive and resistant to chemotherapy. In this study, we investigated the anticancer effect of apigenin on human MDA-MB-231 cells. First, the cytotoxicity of apigenin toward MDA-MB-231 cells was analyzed by MTT assay. Then, the cell cycle and apoptotic effects of apigenin were examined, and the molecular mechanism underlying its anticancer activity was explored. Apigenin inhibited the growth of the cells in a dose-dependent manner, correlating with the cell cycle arrest at the G2-M phase as well as an increase of early apoptosis. The cell-cycle inhibitory effect was highly associated with the increased expression of p21 and decreased expression of CDK6, cyclin D1, and cyclin B1. The induction of apoptosis by apigenin was associated with the upregulated expression of cleaved PARP and cleaved caspase-3, -7, and -9.

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Sorlie T / 2006 / Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer / Mol. Cancer Ther 5:2914~2918 google schola van de Vijver MJ / 2009 / A gene-expression signature as a predictor of survival in breast cancer / N. Engl. J. Med 347:1999~2009 google schola Hudis CA / 2011 / Triple-negative breast cancer: an unmet medical need / Oncologist 16(Suppl 1):1~11 google schola Dent R / 2007 / Triple-negative breast cancer: clinical features and patterns of recurrence / Clin. Cancer Res 13:4429~4434 google schola Papay ZE / 2017 / Study on the pulmonary delivery system of apigeninloaded albumin nanocarriers with antioxidant activity / J. Aerosol. Med. Pulm. Drug Deliv 30:274~288 google schola

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