메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis
Recommendations
Search

논문 기본 정보

Type
Academic journal
Author
Journal
한국미생물생명공학회 한국미생물·생명공학회지 한국미생물·생명공학회지 제47권 제1호 KCI Accredited Journals
Published
2019.1
Pages
34 - 42 (9page)

Usage

cover
Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis
Ask AI
Recommendations
Search

Abstract· Keywords

Report Errors
Apigenin, a common natural product that is found in many plants and vegetables, has been reported to have many biological activities, including antioxidative, anti-inflammatory, and anticancer effects. The triple- negative breast carcinoma cell line MDA-MB-231 is known to be highly invasive and resistant to chemotherapy. In this study, we investigated the anticancer effect of apigenin on human MDA-MB-231 cells. First, the cytotoxicity of apigenin toward MDA-MB-231 cells was analyzed by MTT assay. Then, the cell cycle and apoptotic effects of apigenin were examined, and the molecular mechanism underlying its anticancer activity was explored. Apigenin inhibited the growth of the cells in a dose-dependent manner, correlating with the cell cycle arrest at the G2-M phase as well as an increase of early apoptosis. The cell-cycle inhibitory effect was highly associated with the increased expression of p21 and decreased expression of CDK6, cyclin D1, and cyclin B1. The induction of apoptosis by apigenin was associated with the upregulated expression of cleaved PARP and cleaved caspase-3, -7, and -9.

Contents

No content found

References (36)

Add References
Sorlie T / 2006 / Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer / Mol. Cancer Ther 5:2914~2918 google schola van de Vijver MJ / 2009 / A gene-expression signature as a predictor of survival in breast cancer / N. Engl. J. Med 347:1999~2009 google schola Hudis CA / 2011 / Triple-negative breast cancer: an unmet medical need / Oncologist 16(Suppl 1):1~11 google schola Dent R / 2007 / Triple-negative breast cancer: clinical features and patterns of recurrence / Clin. Cancer Res 13:4429~4434 google schola Papay ZE / 2017 / Study on the pulmonary delivery system of apigeninloaded albumin nanocarriers with antioxidant activity / J. Aerosol. Med. Pulm. Drug Deliv 30:274~288 google schola

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Recently viewed articles

한국인 일본어 학습자의 한자어 유의어 습득
조남성The Japanese Language Association Of Korea2008.03
 A Study on the Improvement of Urban Regeneration in the Historic Districts of Gyeongju -Focusing on the comparison with the Historic Districts of Bangkok-
Tianchin, Thanyaporn, Bak 외 3명The Regional Association of Architectural Institute of Korea2024.06

Comments(0)

0

Write first comments.