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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 557 - 567 (11page)
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TSPAN12, a member of the tetraspanin family, has been highly connected with the pathogenesis of cancer. Its biological function, however, especially in ovarian cancer (OC), has not been well elucidated. In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of TSPAN12 gene expression was significantly correlated with patient survival, suggesting that TSPAN12 might be a potential prognostic marker for OC. Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. Western blot analysis showed that several cyclins and cyclin-dependent kinases (CDK) (e.g., Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. Thus, our data demonstrated that TSPAN12 could be a novel molecular target for the treatment of OC.
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참고문헌 (26)
참고문헌 신청
Bailey, R. L. / 2011 / The emerging role of tetraspanin microdomains on endothelial cells / Biochem. Soc. Trans 39:1667~1673
Banerjee, S. / 2013 / New strategies in the treatment of ovarian cancer : current clinical perspectives and future potential / Clin. Cancer Res 19:961~968
Bendris, N. / 2015 / Cell cycle, cytoskeleton dynamics and beyond : the many functions of cyclins and CDK inhibitors / Cell Cycle 14:1786~1798
Blanchard, J. M. / 2000 / Cyclin A2 transcriptional regulation : modulation of cell cycle control at the G1/S transition by peripheral cues / Biochem. Pharmacol 60:1179~1184
Ewen, M. E. / 2004 / The activities of cyclin D1 that drive tumorigenesis / Trends Mol. Med 10:158~162
Banerjee, S. / 2013 / New strategies in the treatment of ovarian cancer : current clinical perspectives and future potential / Clin. Cancer Res 19:961~968
Bendris, N. / 2015 / Cell cycle, cytoskeleton dynamics and beyond : the many functions of cyclins and CDK inhibitors / Cell Cycle 14:1786~1798
Blanchard, J. M. / 2000 / Cyclin A2 transcriptional regulation : modulation of cell cycle control at the G1/S transition by peripheral cues / Biochem. Pharmacol 60:1179~1184
Ewen, M. E. / 2004 / The activities of cyclin D1 that drive tumorigenesis / Trends Mol. Med 10:158~162
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