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Hepatoprotective potential of Dendropanax morbifera leaf extracts on ethanol-induced liver toxicity in Sprague-Dawley rats
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Type
Academic journal
Author
Yongjae Han (인제대학교 부산백병원 마취통증의학교실) Dong-Eon Lee (Department of Biomedical Sciences College of Medicine and Medical School Chosun University) Chul Hee Choi (조선대학교) LEE HUJANG (경상대학교 수의과대학 동물의학연구소)
Journal
The Korean Society of Preventive Veterinary Medicine 예방수의학회지 예방수의학회지 제45권 제3호 KCI Accredited Journals
Published
2021.9
Pages
115 - 120 (6page)

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Hepatoprotective potential of Dendropanax morbifera leaf extracts on ethanol-induced liver toxicity in Sprague-Dawley rats
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This study investigated the preventive effect of Dendropanax morbifera leaf extracts (DMLEs) drew out with water, 30, 50 and 70% ethanol against alcohol-induced hepatotoxicity in vitro and vivo. The 3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide (MTT) assay was performed to assess cytotoxic activity of DMLEs, and the half-maximal inhibitory concentration (IC50) ranged between 1.11 and 2.08 mg/mL on Hep3B cells. In preventing ethanol-induced-hepatotoxicity on Hep3B cells, 30 and 50% ethanol DMLEs were significantly effective compared to the 5% ethanol treatment control. In addition, the 30% ethanol DMLE was orally provided to rats 30 min prior to the administration of ethanol (3 mL/kg body weight). At 1, 3 and 5 h after ethanol treatment, the plasma levels of ethanol and acetaldehyde were determined. The 30% ethanol DMLE effectively decreased the plasma ethanol levels during 5 h but increased the plasma acetaldehyde levels until 3 h and then significantly decreased at 5 h, as compared to the control. These results indicate that the 30% ethanol DMLE possesses a potent preventive effect against ethanol-induced liver toxicity in Sprague-Dawley rats.
#Dendropanax morbifera #alcohol-induced hepatotoxicity #Hep3B cells #MTT assay

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References (35)

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안영태 / 2005 / 알코올 투여한 쥐에서 발효유의 섭취가 간조직 내항산화 체계에 미치는 영향 / 한국식품과학회지 37(4):631~635 google schola 안나영 / 2014 / Streptozotocin에 의해 유도된 당뇨모델동물에서 황칠나무 (Dendropanax morbifera Leveille)의 열수추출물과 에탄올추출물의 당뇨 질환 개선 효능 / Journal of Nutrition and Health 47(6):394~402 dbpia 채희복 / 2009 / 알코올 간질환 / 대한소화기학회지 53(5):275~282 google schola 홍성화 / 2021 / 알코올로 유도된 간손상에 대한 감꼭지 메탄올 추출물의 보호효과 / 한국식품영양과학회지 50(4):339~346 dbpia 황권택 / 2019 / 약용식물 추출물을 포함한 혼합 복합물의 혈중 알코올 농도와 숙취 해소 효과 / Journal of Chitin and Chitosan 24(1):33~41 dbpia

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