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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 158 - 164 (7page)
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초록· 키워드
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Background/Aims: Endoscopic ultrasonography (EUS)-guided ethanol ablation is gaining popularity for the treatment of focal pancreatic lesions. The aim of this study was to evaluate the safety, feasibility, and treatment response after EUS-guided ethanol injection for small pancreatic neuroendocrine tumors (p-NETs).
Methods: This was a retrospective analysis of a prospectively collected database including 11 consecutive patients with p-NETs who underwent EUS-guided ethanol injection.
Results: EUS-guided ethanol injection was successfully performed in 11 patients with 14 tumors. The final diagnosis was based on histology and clinical signs as follows: 10 non-functioning neuroendocrine tumors and four insulinomas. During follow-up (median, 370 days; range, 152 to 730 days), 10 patients underwent clinical follow-up after treatment, and one patient was excluded because of loss to follow-up. A single treatment session with an injection of 0.5 to 3.8 mL of ethanol resulted in complete responses (CRs) at the 3-month radiologic imaging for seven of 13 tumors (response rate, 53.8%). Multiple treatment sessions performed in three tumors with residual viable enhancing tissue increased the number of tumors with CRs to eight of 13 (response rate, 61.5%). Mild pancreatitis occurred in three of 11 patients.
Conclusions: EUS-guided ethanol injection appears to be a safe, feasible, and potentially effective method for treating small p-NETs in patients who are poor surgical candidates.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Aslanian H / 2005 / EUS-guided ethanol injection of normal porcine pancreas: a pilot study / Gastrointest Endosc 62 : 723 ~ 727
Bettini R / 2011 / Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor / Surgery 150 : 75 ~ 82
Cherenfant J / 2013 / Predicting aggressive behavior in nonfunctioning pancreatic neuroendocrine tumors / Surgery 154 : 785 ~ 791
Deprez PH / 2008 / Successful endoscopic ultrasound-guided ethanol ablation of a sporadic insulinoma / Acta Gastroenterol Belg 71 : 333 ~ 337
Falconi M / 2006 / Well-differentiated pancreatic nonfunctioning tumors/carcinoma / Neuroendocrinology 84 : 196 ~ 211
Bettini R / 2011 / Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor / Surgery 150 : 75 ~ 82
Cherenfant J / 2013 / Predicting aggressive behavior in nonfunctioning pancreatic neuroendocrine tumors / Surgery 154 : 785 ~ 791
Deprez PH / 2008 / Successful endoscopic ultrasound-guided ethanol ablation of a sporadic insulinoma / Acta Gastroenterol Belg 71 : 333 ~ 337
Falconi M / 2006 / Well-differentiated pancreatic nonfunctioning tumors/carcinoma / Neuroendocrinology 84 : 196 ~ 211
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