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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Exposure to ethanol abuse and severe oxidative stress are risk factors for hepatocarcinoma. The aim of this study was to evaluate the effects of S-adenosylmethionine (SAMe) and its combinations with taurine and/or betaine on the level of glutathione (GSH), a powerful antioxidant in the liver, in acute hepatotoxicity induced by ethanol. Methods: To examine the effects of SAMe and its combinations with taurine and/or betaine on ethanol-induced hepatotoxicity, AML12 cells and C57BL/6 mice were pretreated with SAMe, taurine, and/or betaine, followed by ethanol challenge. Cell viability was detected with an MTT assay. GSH concentration and mRNA levels of GSH synthetic enzymes were measured using GSH reductase and quantitative real-time reverse transcriptase-PCR. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were measured with commercially available kits. Results: Pretreatment of SAMe, with or without taurine and/or betaine, attenuated decreases in GSH levels and mRNA expression of the catalytic subunit of glutamate-cysteine ligase (GCL), the rate-limiting enzyme for GSH synthesis, in ethanol-treated cells and mice. mRNA levels of the modifier subunit of GCL and glutathione synthetase were increased in mice treated with SAMe combinations. SAMe, taurine, and/or betaine pretreatment restored serum ALT and AST levels to control levels in the ethanol-treated group. Conclusions: Combinations of SAMe with taurine and/or betaine have a hepatoprotective effect against ethanol-induced liver injury by maintaining GSH homeostasis.
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참고문헌 (50)
참고문헌 신청
Nault JC / 2013 / Hepatocellular benign tumors-from molecular classification to personalized clinical care / Gastroenterology 144:888~902
García-Tevijano ER / 2001 / Hyperhomocysteinemia in liver cirrhosis:mechanisms and role in vascular and hepatic fibrosis / Hypertension 38:1217~1221
Duce AM / 1988 / S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis / Hepatology 8:65~68
Kim SJ / 2009 / Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice / J Hepatol 50:1184~1191
Lee TD / 2004 / Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis / Alcohol Clin Exp Res 28:173~181
García-Tevijano ER / 2001 / Hyperhomocysteinemia in liver cirrhosis:mechanisms and role in vascular and hepatic fibrosis / Hypertension 38:1217~1221
Duce AM / 1988 / S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis / Hepatology 8:65~68
Kim SJ / 2009 / Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice / J Hepatol 50:1184~1191
Lee TD / 2004 / Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis / Alcohol Clin Exp Res 28:173~181
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