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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 81 - 84 (4page)
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초록· 키워드
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Trypanosoma cruzi is the etiological agent of Chagas disease. Epimastigote forms of T. cruzi can be readily cultured in axenic conditions. Ethanol and dimethyl sulfoxide (DMSO) are commonly used solvents employed as vehicles for hydrophobic compounds. In order to produce a reference plot of solvent dependent growth inhibition for T. cruzi research, the growth of epimastigotes was analyzed in the presence of different concentrations of ethanol (0.1-4.0%) and DMSO (0.5-7.5%). The ability of the parasites to resume growth after removal of these solvents was also examined. As expected, both ethanol and DMSO produced a dose-dependent inhibition of cellular growth. Parasites could recover normal growth after 9 days in up to 2% ethanol or 5% DMSO. Since DMSO was better tolerated than ethanol, it is thus recommended to prefer DMSO over ethanol in the case of a similar solubility of a given compound.
목차
Abstract
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Köberle F / 1968 / Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis / Adv Parasitol 6 : 63 ~ 116
[학술지(정기간행물)] - Weiss LM / 2011 / Preface to Chagas disease / Adv Parasitol 76 : 21 ~ 26
[학술지(정기간행물)] - Bern C / 2007 / Evaluation and treatment of Chagas disease in the United States : a systematic reFigview / JAMA 298 : 2171 ~ 2181
[학술지(정기간행물)] - Díaz-Urrutia CA / 2012 / Biological and chemical study of fused tri-and tetracyclic indazoles and analogues with important antiparasitic activity / Spectrochim Acta A Mol Biomol Spectrosc 95 : 670 ~ 678
[학술지(정기간행물)] - Vigueira PA / 2012 / Effects of the green tea catechin()-epigallocatechin gallate on Trypanosoma brucei / Int J Parasitol Drugs Drug Resist 2 : 225 ~ 229
[학술지(정기간행물)] - Weiss LM / 2011 / Preface to Chagas disease / Adv Parasitol 76 : 21 ~ 26
[학술지(정기간행물)] - Bern C / 2007 / Evaluation and treatment of Chagas disease in the United States : a systematic reFigview / JAMA 298 : 2171 ~ 2181
[학술지(정기간행물)] - Díaz-Urrutia CA / 2012 / Biological and chemical study of fused tri-and tetracyclic indazoles and analogues with important antiparasitic activity / Spectrochim Acta A Mol Biomol Spectrosc 95 : 670 ~ 678
[학술지(정기간행물)] - Vigueira PA / 2012 / Effects of the green tea catechin()-epigallocatechin gallate on Trypanosoma brucei / Int J Parasitol Drugs Drug Resist 2 : 225 ~ 229
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UCI(KEPA) : I410-ECN-0101-2017-513-002242156