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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 384 - 389 (6page)
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The Nogo-B receptor (NgBR) is necessary for not only Nogo-B-mediated angiogenesis but also vascular endothelial growth factor (VEGF) -induced angiogenesis. However, the molecular mechanisms underlying the regulatory role of the VEGF-NgBR axis in angiogenesis are not fully understood.
Here, we report that miR-26a serves as a critical regulator of VEGF-mediated angiogenesis through directly targeting NgBR in endothelial cells (ECs). Stimulation of ECs by VEGF increased the expression of NgBR and decreased the expression of miR-26a. In addition, miR-26a decreased the VEGF-induced migration and proliferation of ECs. Moreover, miR-26a overexpression in ECs decreased the VEGF-induced phosphorylation of the endothelial nitric oxide synthase (eNOS) and the production of nitric oxide, which is important for angiogenesis. Overall, these data suggest that miR-26a plays a key role in VEGF-mediated angiogenesis through the modulation of eNOS activity, which is mediated by its ability to regulate NgBR expression by directly targeting the NgBR 3’-UTR.
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참고문헌 (27)
참고문헌 신청
Carmeliet P / 2005 / Angiogenesis in life, disease and medicine / Nature 438:932~936
Iruela-Arispe ML / 1997 / Angiogenesis : a dynamic balance of stimulators and inhibitors / Thromb Haemost 78:672~677
Herbert SP / 2011 / Molecular control of endothelial cell behaviour during blood vessel morphogenesis / Nat Rev Mol Cell Biol 12:551~564
Kim J / 2008 / X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival / Circ Res 102:896~904
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407:249~257
Iruela-Arispe ML / 1997 / Angiogenesis : a dynamic balance of stimulators and inhibitors / Thromb Haemost 78:672~677
Herbert SP / 2011 / Molecular control of endothelial cell behaviour during blood vessel morphogenesis / Nat Rev Mol Cell Biol 12:551~564
Kim J / 2008 / X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival / Circ Res 102:896~904
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407:249~257
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