지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 191 - 196 (6page)
이용수
초록· 키워드
오류제보하기
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and critical for normal embryonic development and repair of pathophysiological conditions in adults. Although phospholipase D (PLD) activity has been implicated in angiogenic processes, its role in VEGF signaling during angiogenesis in mammals is unclear. Here, we found that silencing of PLD2 by siRNA blocked VEGF-mediated signaling in immortalized human umbilical vein endothelial cells (iHUVECs).
Also, VEGF-induced endothelial cell survival, proliferation, migration, and tube formation were inhibited by PLD2 silencing.
Furthermore, while Pld2-knockout mice exhibited normal development, loss of PLD2 inhibited VEGF-mediated ex vivo angiogenesis. These findings suggest that PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Ferrara N / 2003 / The biology of VEGF and its receptors / Nat Med 9:669~676
Olsson AK / 2006 / VEGF receptor signalling-in control of vascular function / Nat Rev Mol Cell Biol 7:359~371
Carmeliet P / 2011 / Molecular mechanisms and clinical applications of angiogenesis / Nature 473:298~307
Carmeliet P / 2005 / Angiogenesis in life, disease and medicine / Nature 438:932~936
Ribatti D / 2009 / Morphological and molecular aspects of physiological vascular morphogenesis / Angiogenesis 12:101~111
Olsson AK / 2006 / VEGF receptor signalling-in control of vascular function / Nat Rev Mol Cell Biol 7:359~371
Carmeliet P / 2011 / Molecular mechanisms and clinical applications of angiogenesis / Nature 473:298~307
Carmeliet P / 2005 / Angiogenesis in life, disease and medicine / Nature 438:932~936
Ribatti D / 2009 / Morphological and molecular aspects of physiological vascular morphogenesis / Angiogenesis 12:101~111
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis
BMB Reports
2017 .07
-
Structure and function of vascular endothelial growth factor and its receptor system
BMB Reports
2018 .01
-
Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
Experimental and Molecular Medicine
2016 .01
-
Pleckstrin homology domain of phospholipase D2 is a negative regulator of focal adhesion kinase
BMB Reports
2021 .01
-
CLEC4a as a novel therapeutic target in angiogenesis: A new challenge with antibody-based targeting of VEGF
한국생물공학회 학술대회
2017 .10
-
Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration and microtubule stability
Experimental and Molecular Medicine
2022 .08
-
Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer
Experimental and Molecular Medicine
2022 .09
-
Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis
BMB Reports
2017 .01
-
Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis
Experimental and Molecular Medicine
2017 .01
-
Anti-angiogenic Mechanism of IPS-05002, a Novel Antagonist against Integrin α5β1, Determined by ProteoChip-based Antibody Array
BioChip Journal
2016 .01
-
Flow goes forward and cells step backward: endothelial migration
Experimental and Molecular Medicine
2022 .06
-
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
Experimental and Molecular Medicine
2021 .09
-
청소년 개인음향기기 이용습관, 청력손실 원인과 청력보호 이해에 관한 실태조사 및 설문지 개발
한국음향학회지
2016 .01
-
융합 단백질을 이용한 재조합 인간 혈관내피세포 성장인자의 정제공정 개발
화학공학
2017 .01
-
6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis
BMB Reports
2019 .01
-
심근경색 조직재생을 위한 VEGF 나노입자 방출 약물 전달 패치
한국생산제조학회 학술발표대회 논문집
2022 .07
-
TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome
Experimental and Molecular Medicine
2020 .01
-
Adenosine-Prefabricated Adipose Tissue Improves Fat Graft Survival by Promoting VEGF-Dependent Angiogenesis
조직공학과 재생의학
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0