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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 208 - 213 (6page)
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초록· 키워드
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Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGFreceptor- 1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertrophy. In this study, we identified the prohypertrophic role of miR-374 using neonatal rat ventricular myocytes (NRVMs). Our results showed that overexpression of miR-374 activated G protein-coupled receptor-mediated prohypertrophic pathways by the inhibition of VEGFR1-dependent regression pathways. Luciferase assays revealed that miR-374 could directly target the 3’-untranslated regions of VEGFR1 and cGMP-dependent protein kinase-1. Collectively, these findings demonstrated that miR-374 was a novel pro-hypertrophic microRNA functioning to suppress the VEGFR1-mediated regression pathway.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cantley LC / 2002 / The phosphoinositide 3-kinase pathway / Science 296 : 1655 ~ 1657
Carmeliet P / 2000 / Molecular basis of angiogenesis. Role of VEGF and VE-cadherin / Ann N Y Acad Sci 902 : 249 ~ 262
Castaldi A / 2014 / MicroRNA- 133 modulates the ?1-adrenergic receptor transduction cascade / Circ Res 115 : 273 ~ 283
Ferrara N / 1999 / Molecular and biological properties of vascular endothelial growth factor / J Mol Med 77 : 527 ~ 543
Frey N / 2003 / Cardiac hypertrophy: the good, the bad, and the ugly / Annu Rev Physiol 65 : 45 ~ 79
Carmeliet P / 2000 / Molecular basis of angiogenesis. Role of VEGF and VE-cadherin / Ann N Y Acad Sci 902 : 249 ~ 262
Castaldi A / 2014 / MicroRNA- 133 modulates the ?1-adrenergic receptor transduction cascade / Circ Res 115 : 273 ~ 283
Ferrara N / 1999 / Molecular and biological properties of vascular endothelial growth factor / J Mol Med 77 : 527 ~ 543
Frey N / 2003 / Cardiac hypertrophy: the good, the bad, and the ugly / Annu Rev Physiol 65 : 45 ~ 79
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