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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 560 - 565 (6page)
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Benign prostatic hyperplasia (BPH), a common disease in elderly males, is accompanied by non-malignant growth of prostate tissues, subsequently causing hypoxia and angiogenesis. Although VEGF-related angiogenesis is one of the therapeutic targets of prostate cancer, there is no previous study targeting angiogenesis for treatment of BPH. Dihydrotestosterone (DHT)- induced expressions of vascular endothelial growth factor (VEGF) in prostate epithelial RWPE-1 cells and human umbilical vascular endothelial cells (HUVECs). Conditioned media (CM) from DHT-treated RWPE-1 cells were transferred to HUVECs. Then, 6SL inhibited proliferation, VEGFR-2 activation, and tube formation of HUVECs transferred with CM from DHT-treated RWPE-1 cells. In the rat BPH model, 6SL reduced prostate weight, size, and thickness of the prostate tissue. Formation of vessels in prostatic tissues were also reduced with 6SL treatment. We found that 6SL has an ameliorative effect on in vitro and in vivo the BPH model via inhibition of VEGFR-2 activation and subsequent angiogenesis. These results suggest that 6SL might be a candidate for development of novel BPH drugs.
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참고문헌 (41)
참고문헌 신청
Emberton M / 2003 / Benign prostatic hyperplasia : a progressive disease of aging men / Urology 61:267~273
O'Leary MP / 2003 / Lower urinary tract symptoms/benign prostatic hyperplasia : maintaining symptom control and reducing complications / Urology 62:15~23
Keledjian K / 2001 / Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin / Prostate 48:71~78
Carson C 3rd / 2003 / The role of dihydrotestosterone in benign prostatic hyperplasia / Urology 61:2~7
Zaman Huri H / 2014 / Drug-related problems in patients with benign prostatic hyperplasia : a cross sectional retrospective study / PLoS One 9:e86215
O'Leary MP / 2003 / Lower urinary tract symptoms/benign prostatic hyperplasia : maintaining symptom control and reducing complications / Urology 62:15~23
Keledjian K / 2001 / Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin / Prostate 48:71~78
Carson C 3rd / 2003 / The role of dihydrotestosterone in benign prostatic hyperplasia / Urology 61:2~7
Zaman Huri H / 2014 / Drug-related problems in patients with benign prostatic hyperplasia : a cross sectional retrospective study / PLoS One 9:e86215
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