지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 590 - 595 (6page)
이용수
초록· 키워드
오류제보하기
High-mobility group box-1 (HMGB-1) is expressed in almost all cells, and its dysregulated expression correlates with inflammatory diseases, ischemia, and cancer. Some of these conditions accompany HMGB-1-mediated abnormal angiogenesis. Thus far, the mechanism of HMGB-1-induced angiogenesis remains largely unknown. In this study, we performed time-dependent DNA microarray analysis of endothelial cells (ECs) after HMGB-1 or VEGF treatment. The pathway analysis of each gene set upregulated by HMGB-1 or VEGF showed that most HMGB-1-induced angiogenic pathways were also activated by VEGF, although the activation time and gene sets belonging to the pathways differed. In addition, HMGB-1 upregulated some VEGFR signaling-related angiogenic factors including EGR1 and, importantly, novel angiogenic factors, such as ABL2, CEACAM1, KIT, and VIPR1, which are reported to independently promote angiogenesis under physiological and pathological conditions. Our findings suggest that HMGB-1 independently induces angiogenesis by activating HMGB-1-specific angiogenic factors and also functions as an accelerator for VEGF-mediated conventional angiogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bergers G / 2008 / Modes of resistance to anti-angiogenic therapy / Nat Rev Cancer 8 : 592 ~ 603
Biscetti F / 2011 / Therapeutic potential of high mobility group box-1 in ischemic injury and tissue regeneration / Curr Vasc Pharmacol 9 : 677 ~ 681
Bonapace L / 2014 / Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis / Nature 515 : 130 ~ 133
Cai J / 2015 / HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4 / Arterioscler Thromb Vasc Biol 35 : 2
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407 : 249 ~ 257
Biscetti F / 2011 / Therapeutic potential of high mobility group box-1 in ischemic injury and tissue regeneration / Curr Vasc Pharmacol 9 : 677 ~ 681
Bonapace L / 2014 / Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis / Nature 515 : 130 ~ 133
Cai J / 2015 / HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4 / Arterioscler Thromb Vasc Biol 35 : 2
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407 : 249 ~ 257
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Non-histone protein HMGB1 inhibits the repair of damaged DNA by cisplatin in NIH-3T3 murine fibroblasts
BMB Reports
2016 .01
-
Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses
BMB Reports
2016 .01
-
Ultrasound-Responsive Nanobubbles for Releasing Intact HMGB1 in Cancer Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Backbone assignment of HMGB1 A-box and molecular interaction with Hoxc9DBD studied by paramagnetic probe
Journal of the Korean Magnetic Resonance Society
2021 .01
-
Ultrasound-responsive Nanoparticles for Releasing Intact HMGB1 in Cancer Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
29-kDa FN-f inhibited autophagy through modulating localization of HMGB1 in human articular chondrocytes
BMB Reports
2018 .01
-
Modulation of HMGB1 Activity for Successful Outcome of Islet Transplantation
한국생물공학회 학술대회
2015 .10
-
Loss of phospholipase D2 impairs VEGF-induced angiogenesis
BMB Reports
2016 .01
-
Modulation of HMGB1 activity using natural polysaccharide glycyrrhizin for successful outcome of islet transplantation
한국고분자학회 학술대회 연구논문 초록집
2015 .10
-
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3
Experimental and Molecular Medicine
2021 .08
-
Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis
BMB Reports
2017 .07
-
CLEC4a as a novel therapeutic target in angiogenesis: A new challenge with antibody-based targeting of VEGF
한국생물공학회 학술대회
2017 .10
-
HMGB1 modulation using glycyrrhizin-chitosan bioconjugate for successful outcomes of transplanted pancreatic islets
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
Structure and function of vascular endothelial growth factor and its receptor system
BMB Reports
2018 .01
-
Relapse of pathological angiogenesis: functional role of the basement membrane and potential treatment strategies
Experimental and Molecular Medicine
2021 .02
-
Comparison of Angiogenic Activities of Three Neuropeptides, Substance P, Secretoneurin, and Neuropeptide Y Using Myocardial Infarction
조직공학과 재생의학
2018 .01
-
M. aeruginosa Extracted Crude Microcystins Inhibits lipid Accumulation and Angiogenesis by Suppressing Angiogenesis and Adipogenesis Promoting Signaling Molecules in HUVECs and 3T3-L1 cells
한국생물공학회 학술대회
2018 .04
-
Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
Experimental and Molecular Medicine
2016 .01
-
A Study on Trophoblast Invasion in Angiogenesis Induced Endothelial Cell
한국생물공학회 학술대회
2022 .09
-
Angiogenic Metal Nanoparticles Controlling Intracellular Gene Activation in Stem Cells
한국생물공학회 학술대회
2022 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0