메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Enami Kaneko (Department of Obstetrics and Gynecology Akita University Graduate School of Medicine Akita Japan) Naoki Sato (Department of Obstetrics and Gynecology Akita University Graduate School of Medicine Akita Japa) Tae Sugawara (Department of Obstetrics and Gynecology Akita University Graduate School of Medicine Akita Japan) Aya Noto (Department of Obstetrics and Gynecology Akita Kousei Medical Center Akita Japan) Kazue Takahashi (Department of Obstetrics and Gynecology Hiraka General Hospital Akita Japan) Kenichi Makino (Department of Obstetrics and Gynecology Akita University Graduate School of Medicine Akita Japan) Yukihiro Terada (Department of Obstetrics and Gynecology Akita University Graduate School of Medicine Akita Japan)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.32 No.6
발행연도
2021.11
수록면
1 - 13 (13page)
DOI
https://doi.org/10.3802/jgo.2021.32.e79

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Objective: The antitumor effects of anti-PD-1 antibody against mismatch repair deficiency (MMR-D)-associated cancers have been reported. MMR-D is found in approximately20%?30% of endometrial carcinomas (ECs) and frequently occurs due to promoter hypermethylation ( -PHM). ECs with -PHM are classified according to the molecular screening of Lynch syndrome (LS), but few detailed reports are available. The purpose of this study was to clarify the clinical features of EC with -PHM. Methods: Immunohistochemistry of MMR proteins (MLH1, MSH2, MSH6, and PMS2) was performed on specimens from 527 ECs treated at our university hospital from 2003 to 2018. methylation analysis was added to cases with MLH1/PMS2 loss. ECs were classified as follows: cases that retained MMR proteins as “MMR-proficient;” cases with MLH1/PMS2 loss and -PHM as “met-EC;” and cases with other MMR protein loss and MLH1/PMS2 loss without -PHM as “suspected-LS.” The clinical features, including long-term prognosis, of each group, were analyzed. Results: Accordingly, 419 (79.5%), 65 (12.3%), and 43 (8.2%) cases were categorized as “MMR-proficient,” “suspected-LS,” and “met-EC,” respectively. Significantly, “met-EC” had a lower proportion of grade 1 tumors (37.5%) and a higher proportion of stage III/IV tumors (37.2%) than the other groups. The overall and progression-free survival of “met-EC” were significantly worse than those of “suspected-LS” in all cases. Conclusion: In ECs with MMR-D, “met-ECs” were a subgroup with a poorer prognosis than “suspected-LS.” “Met-ECs” would be the main target for anti-PD-1 antibody treatment, and its clinical susceptibility should be verified individually.
#Endometrial Neoplasms #DNA Mismatch Repair #Methylation #Prognosis

목차

등록된 정보가 없습니다.

참고문헌 (32)

참고문헌 신청
Le DT / 2017 / Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade / Science 357:409~413 google schola Xicola RM / 2019 / Implication of DNA repair genes in Lynch-like syndrome / Fam Cancer 18:331~342 google schola Porkka N / 2019 / Epidemiological, clinical and molecular characterization of Lynch-like syndrome: a population-based study / Int J Cancer 145:87~98 google schola Bruegl AS / 2014 / Evaluation of clinical criteria for the identification of Lynch syndrome among unselected patients with endometrial cancer / Cancer Prev Res (Phila) 7:686~697 google schola Buchanan DD / 2014 / Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing / J Clin Oncol 32:90~100 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0