지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.5
- 수록면
- 1 - 15 (15page)
- DOI
- https://doi.org/10.3802/jgo.2022.33.e29
이용수
초록· 키워드
오류제보하기
Objective: Recent studies have detailed the genomic landscape of endometrial cancer (EC); however, no study has focused on genetic alterations in advanced EC. We performed genomic profiling of patients with advanced EC using targeted next-generation sequencing (NGS). Methods: Archival tissue samples from 21 patients diagnosed with stage III and IV EC were obtained and subjected to NGS. Our data and the cancer genome atlas dataset were combined, and somatic mutation patterns were analyzed and compared according to the stage and histological type. Additionally, survival effects of specific mutated genes were analyzed.
Results: Somatic mutation patterns of 38 genes were identified in 263 EC samples, and the most commonly mutated genes were and . was the most common in endometrioid histology, while was the most commonly mutated gene in serous histology. The mutation rates of and were significantly higher in advanced EC sample than in stage I samples (22.5% vs. 4.3% [p<0.001] and 8.4% vs. 1.4% [p=0.021], respectively). Survival analysis of the total population and endometrioid subgroup revealed that patients with mutations had significantly shorter survival than did those without mutations (p=0.005 and p<0.001, respectively).
Conclusion: mutations might have a role in dismal prognosis of advanced EC.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The frequency of POLE-mutation in endometrial carcinoma and prognostic implications: a systemic review and meta-analysis
Journal of Pathology and Translational Medicine
2020 .01
-
Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
Gut and Liver
2019 .01
-
Current landscape and future perspective of sentinel node mapping in endometrial cancer
Journal of Gynecologic Oncology
2018 .01
-
MLH1 promoter hypermethylation predicts poorer prognosis in mismatch repair deficiency endometrial carcinomas
Journal of Gynecologic Oncology
2021 .11
-
Regulatory Network of MicroRNAs, Target Genes, Transcription Factors and Host Genes in Endometrial Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Endometrial cancer risk and survival by tumor MMR status
Journal of Gynecologic Oncology
2018 .01
-
Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study
Journal of Gynecologic Oncology
2022 .05
-
C-kit Mutations in Endometrial Cancer: Correlation with Tumor Histologic Type
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Breast Cancer Gene Analysis through Next Generation Sequencing
대한외과학회 학술대회 초록집
2021 .05
-
Use of Somatic Mutation Profiling Panels in the Personalized Management of Cancer Patients
대한임상종양학회 학술대회지
2017 .02
-
Patterns of Esophageal Cancer in the National Cancer Institute at the University of Gezira, in Gezira State, Sudan, in 1999-2012
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Next-generation sequencing: recent applications to the analysis of colorectal cancer in Korea
대한임상종양학회 학술대회지
2021 .06
-
Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test
Cancer Research and Treatment
2020 .01
-
Frequency of K-RAS and N-RAS Gene Mutations in Colorectal Cancers in Southeastern Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The Spectrum of Genetic Mutations in Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Enhanced Antioxidant and Anticancer Properties of Processed Eucommiae Cortex
Natural Product Sciences
2019 .06
-
Prevalence of PALB2 Germline Mutations in Early-onset and Familial Breast/Ovarian Cancer Patients from Pakistan
Cancer Research and Treatment
2019 .01
-
Clinical Features of Li-Fraumeni Syndrome in Korea
Cancer Research and Treatment
2024 .01
-
Genomic Signatures from Clinical Tumor Sequencing in Patients with Breast Cancer Having Germline BRCA1/2 Mutation
Cancer Research and Treatment
2023 .01
-
Novel Germline Mutations of BRCA1 and BRCA2 in Korean Familial Breast Cancer Patients
전남의대학술지
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0