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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 40 - 45 (6page)
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초록· 키워드
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Objective: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not determined. Correlations between MMR-related protein expression and clinicopathological factors of endometrial cancers are analyzed in the present study.
Methods: A total of 191 endometrial cancer tissues treated between 1990 and 2007 in our hospital were enrolled. Immunoreactions for MSH2, MLH1, MSH6, and PMS2 on tissue microarray specimens and clinicopathological features were analyzed retrospectively.
Results: Seventy-six cases (40%) had at least one immunohistochemical alteration in MMR proteins (MMR-deficient group). There were statistically significant differences of histology, International Federation of Gynecology and Obstetrics (FIGO) stage, and histological grade between MMR-deficient group and the other cases (MMR-retained group). Response rate of first-line chemotherapy in evaluable cases was slightly higher in MMR-deficient cases (67% vs. 44%, p=0.34). MMR-deficient cases had significantly better progression-free and overall survival (OS) compared with MMR-retained cases. Multivariate analysis revealed MMR status was an independent prognostic factor for OS in endometrial cancers.
Conclusion: MMR-related proteins expression was identified as an independent prognostic factor for OS, suggesting that MMR was a key biomarker for further investigations of endometrial cancers.
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참고문헌 (31)
참고문헌 신청
Matsuda A / 2013 / Cancer incidence and incidence rates in Japan in 2007: a study of 21 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project / Jpn J Clin Oncol 43:328~336
Hirai Y / 2008 / Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer / Cancer Sci 99:1715~1719
OECDiLibrary / Health at a glance
Japanese Gynecologic Oncology Committee / 2008 / Annual report of endometrial carcinoma patients in 2006 / Acta Obstet Gynaecol Jpn 60:1034~1040
Brinton LA / 2013 / Etiologic heterogeneity in endometrial cancer:evidence from a Gynecologic Oncology Group trial / Gynecol Oncol 129:277~284
Hirai Y / 2008 / Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer / Cancer Sci 99:1715~1719
OECDiLibrary / Health at a glance
Japanese Gynecologic Oncology Committee / 2008 / Annual report of endometrial carcinoma patients in 2006 / Acta Obstet Gynaecol Jpn 60:1034~1040
Brinton LA / 2013 / Etiologic heterogeneity in endometrial cancer:evidence from a Gynecologic Oncology Group trial / Gynecol Oncol 129:277~284
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